This trial is evaluating whether Pembrolizumab will improve 1 primary outcome in patients with Glioblastoma. Measurement will happen over the course of one year.
This trial requires 90 total participants across 4 different treatment groups
This trial involves 4 different treatments. Pembrolizumab is the primary treatment being studied. Participants will be divided into 3 treatment groups. Some patients will receive a placebo treatment. The treatments being tested are in Phase 2 and have already been tested with other people.
"The most important sign of glioblastoma is the appearance of symptoms. The main symptoms and diagnostic criteria are headache, lethargy, focal neurological deficits and deterioration. In the case of the last symptom, the patients are urgently investigated and the standard diagnostic tests are performed, particularly for patients who do not have a head trauma problem. Because a recent (December 2017) article (1, 2, 3) states that the symptoms of glioblastoma may appear years before this disease can be diagnosed, a detailed medical interview, including the history of any head trauma (brain trauma), should first be performed in patients with these symptoms." - Anonymous Online Contributor
"Current research suggests there is a relationship between schizophrenia and glioblastoma. We need to find which factors might contribute to the increased risk of glioblastoma in patients diagnosed with schizophrenia. If we manage schizophrenia appropriately, the prognostic impact of schizophrenia on glioblastoma may no longer be present. There is also some hope that anti-inflammatory and immunosuppressive therapies may be used to combat brain tumors. The prognosis for many types of brain tumor, including glioblastoma, is poor; it has a median survival of only 3.5 to 4.3 years. Achieving a cure, while difficult, is still possible." - Anonymous Online Contributor
"The U.S. rate of incidence of anaplastic astrocytoma was 7.24 per 100,000 per year, and the rate of glioblastoma was 2.35 per 100,000 per year. The incidence of anaplastic astrocytoma increased significantly in males (3.27 per 100,000) and people 65 years old and older (9.51 per 100,000). The number of new cases per year of glioblastoma has decreased significantly for both males (2.13 per 100,000) and females (1.95 per 100,000) but only in ages 65 years old and older (0.47 per 100,000)." - Anonymous Online Contributor
"Glioblastoma is most frequently caused by a combination of genetic mutations and environmental exposures. Exposure to ionizing radiation and cigarette smoking increase the risk for developing the disease." - Anonymous Online Contributor
"Complete surgical resection of tumor is the most effective treatment for patients with glioblastoma. Surgery combined with radiation and chemotherapy improves survival rates, but treatment with only surgery does not improve survival compared with surgery without radiation or chemotherapy. Chemotherapy is usually needed to improve survival; however, the addition of radiation does not improve survival even if it is combined with chemotherapy. A randomized study will be conducted with longer follow-up time to evaluate whether and when to stop chemotherapy and whether the survival benefit is maintained when chemotherapy is discontinued." - Anonymous Online Contributor
"Glioblastoma is a type of brain tumour that arises from glial cells that line the brain and spinal cord. Most glioblastomas form slowly over several years. It can be distinguished from other brain tumours by features such as consistency, shape, the presence of cysts, loss of the corpus callosum and the cerebrospinal fluid level. Most patients have symptoms such as headache, nausea, loss of appetite and changes in bowel or bladder habits. Glioblastoma is thought to arise from a simple combination of genetic and environmental factors, particularly DNA damage and loss of tumour suppressor genes. Diagnostic imaging techniques include computed tomography scans and magnetic resonance imaging scans." - Anonymous Online Contributor
"As more treatments are tested in clinical trials, there is an increasing need for clinical trial criteria for glioblastoma which will need to reflect the heterogeneity within the disease. The need for clinical trial participation, as we await the next generation of therapies is crucial." - Anonymous Online Contributor
"The age at diagnosis of glioblastoma was 55.10 yr, with a range of 22.0-71 yr. The incidence rate of glioblastoma in Western countries and the incidence of a malignant glioma in patients younger than 45 yr are 5-10%, and these diseases are often diagnosed in younger patients. The incidence rate in Japan is lower (0.2%), but the peak age is advanced (70 yr). The peak age of individuals diagnosed with glioblastoma in Israel is younger than that in Western countries." - Anonymous Online Contributor
"Results from a recent clinical trial of the study suggest that, in most European and North American population, the risk of developing GBM is not a significant concern." - Anonymous Online Contributor
"Results from a recent clinical trial suggest that pembrolizumab is well tolerated and may be beneficial for patients with recurrent GBM and for patients in long-term care." - Anonymous Online Contributor
"In this retrospective meta-analysis, there is no significant difference in outcomes between patients treated with combination of pembrolizumab and other therapies and patients treated with pembrolizumab alone. In this subset of patients, pembrolizumab should be considered the preferred treatment regimen." - Anonymous Online Contributor
"The overall number of publications on GBM-related research (as measured by PubMed Central) is in line with all of the recent literature on the subject, suggesting that there has been no significant break in the pace of GLI research since 2006." - Anonymous Online Contributor