← Back to Search

Proteasome Inhibitor

Marizomib for Glioblastoma (MIRAGE Trial)

Phase 3
Waitlist Available
Led By Patrick Roth
Research Sponsored by European Organisation for Research and Treatment of Cancer - EORTC
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up from randomization until progression, assessed up to 49 months
Awards & highlights

MIRAGE Trial Summary

This trial is testing a new combination of drugs to see if it is safe and effective for treating glioblastoma, a type of brain cancer.

Eligible Conditions
  • Glioblastoma

MIRAGE Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~from randomization until progression, assessed up to 49 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and from randomization until progression, assessed up to 49 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Overall Survival (OS)
Secondary outcome measures
Health-related Quality of Life (HRQol)
Mini Mental State Examination (MMSE)
Progression Free Survival (PFS)

Side effects data

From 2023 Phase 3 trial • 749 Patients • NCT03345095
67%
Nausea
62%
Fatigue
53%
Headache
52%
Vomiting
41%
Constipation
38%
Hallucination
29%
Insomnia
24%
Gait Disturbance
24%
Alopecia
23%
Dizziness
23%
Ataxia
21%
Decreased Appetite
20%
Confusional State
16%
Weight Decreased
16%
Aphasia
15%
Diarrhoea
15%
Dysarthria
14%
Balance Disorder
11%
Asthenia
11%
Fall
11%
Pyrexia
11%
Anxiety
11%
Seizure
10%
Cough
10%
Muscular Weakness
9%
Thrombocytopenia
8%
Vertigo
8%
Platelet Count Decreased
8%
Hemiparesis
7%
Hallucination, Visual
7%
Diplopia
6%
Arthralgia
6%
Somnolence
6%
Memory Impairment
6%
Oedema Peripheral
6%
Tremor
6%
Pruritus
6%
Vision Blurred
6%
Cognitive Disorder
6%
Disturbance In Attention
6%
Depression
6%
Rash
6%
Back Pain
6%
Agitation
6%
Lymphopenia
6%
Radiation Skin Injury
6%
Alanine Aminotransferase Increased
5%
Nightmare
5%
Hypertension
5%
Dysgeusia
5%
Lymphocyte Count Decreased
5%
Brain Oedema
5%
Anaemia
5%
Dyspepsia
4%
Neutropenia
4%
Urinary Tract Infection
4%
Abdominal Pain Upper
4%
Influenza Like Illness
4%
Dry Mouth
4%
Delirium
4%
Paraesthesia
4%
Tinnitus
4%
Neck Pain
4%
Injection Site Pain
4%
Neutrophil Count Decreased
4%
Hyperglycaemia
4%
Infusion Related Reaction
4%
Weight Increased
4%
Myalgia
3%
Blood Creatinine Increased
3%
Hypoaesthesia
3%
Lacrimation Increased
3%
Gamma-Glutamyltransferase Increased
3%
Urinary Incontinence
3%
Infusion Site Pain
3%
Dyspnoea
3%
Dysphonia
3%
Sleep Disorder
3%
Hypersomnia
3%
Deep Vein Thrombosis
3%
Herpes Zoster
3%
Lethargy
3%
Dermatitis
3%
Dry Skin
3%
Injection Site Reaction
3%
Amnesia
3%
Leukopenia
3%
Malignant Neoplasm Progression
3%
Abdominal Pain
3%
Face Oedema
3%
Bronchitis
3%
Aspartate Aminotransferase Increased
3%
Dehydration
3%
Speech Disorder
3%
Erythema
2%
Pneumonia
2%
Dysphagia
2%
Oropharyngeal Pain
2%
Oral Candidiasis
2%
Malaise
2%
Nasopharyngitis
2%
White Blood Cell Count Decreased
2%
Irritability
2%
Muscle Spasms
2%
Hot Flush
2%
Photopsia
2%
General Physical Health Deterioration
2%
Motor Dysfunction
2%
Thrombophlebitis Superficial
2%
Pain In Jaw
2%
Abnormal Dreams
2%
Palpitations
2%
Thrombophlebitis
2%
Hypoacusis
2%
Cushingoid
2%
Hypotension
2%
Gastrooesophageal Reflux Disease
2%
Chills
2%
Pain
2%
Depressed Mood
2%
Photophobia
2%
Hypokalaemia
2%
Pain In Extremity
2%
Rash Maculo-Papular
2%
Personality Change
2%
Epilepsy
2%
Candida Infection
2%
Neurological Decompensation
2%
Nystagmus
2%
Phlebitis
2%
Depressed Level Of Consciousness
2%
Nervous System Disorder
2%
Upper Respiratory Tract Infection
2%
Visual Impairment
2%
Blood Bilirubin Increased
2%
Ear Pain
2%
Pulmonary Embolism
1%
Neuralgia
1%
Dyspraxia
1%
Anosmia
1%
Slow Speech
1%
Lumbar Vertebral Fracture
1%
Cystitis
1%
Eye Irritation
1%
Toothache
1%
Catheter Site Thrombosis
1%
Ear Discomfort
1%
Folliculitis
1%
Infection
1%
Oral Fungal Infection
1%
Coordination Abnormal
1%
Hypophosphataemia
1%
Joint Swelling
1%
Nervousness
1%
Gastroenteritis
1%
Oral Herpes
1%
Haematuria
1%
Nasal Congestion
1%
Visual Field Defect
1%
Dysaesthesia
1%
Psychomotor Hyperactivity
1%
Bradyphrenia
1%
Delusion
1%
Vasogenic Cerebral Oedema
1%
Paranoia
1%
Pneumothorax
1%
Pancytopenia
1%
Abdominal Distension
1%
Gastritis
1%
Rectal Haemorrhage
1%
Peripheral Swelling
1%
Device Related Infection
1%
Contusion
1%
Radiation Necrosis
1%
Blood Potassium Decreased
1%
Hydrocephalus
1%
Presyncope
1%
Pollakiuria
1%
Proteinuria
1%
Embolism
1%
Tachycardia
1%
Dry Eye
1%
Vascular Pain
1%
Skin Toxicity
1%
Rhinitis
1%
Hypomagnesaemia
1%
Mucosal Inflammation
1%
Sepsis
1%
Flatulence
1%
Injection Site Bruising
1%
Facial Asymmetry
1%
Monoparesis
1%
Cerebral Haemorrhage
1%
Encephalopathy
1%
Hiccups
1%
Haematoma
1%
Haematemesis
1%
Haemorrhoids
1%
Sinus Tachycardia
1%
Glioblastoma
1%
Disorientation
1%
Rhinorrhoea
1%
Dermatitis Acneiform
1%
Perseveration
1%
Generalised Tonic-Clonic Seizure
1%
Productive Cough
1%
Eye Pain
1%
Sinusitis
1%
Catheter Site Pain
1%
Respiratory Tract Infection
1%
Transaminases Increased
1%
Vitamin B12 Deficiency
1%
Syncope
1%
Taste Disorder
1%
Micturition Urgency
1%
Gingival Bleeding
1%
Hypoaesthesia Oral
1%
Feeling Cold
1%
Oedema
1%
Peripheral Sensory Neuropathy
1%
Akathisia
1%
Mouth Ulceration
1%
Infusion Site Phlebitis
1%
Procedural Pain
1%
Hyperkalaemia
1%
Gastroenteritis Viral
1%
Blood Lactate Dehydrogenase Increased
1%
C-Reactive Protein Increased
1%
Vestibular Disorder
1%
Intracranial Pressure Increased
1%
Stomatitis
1%
Chest Pain
1%
Pharyngitis
1%
Myopathy
1%
Lower Respiratory Tract Infection
1%
Head Injury
1%
White Blood Cell Count Increased
1%
Blood Alkaline Phosphatase Increased
1%
Hyponatraemia
1%
Facial Paralysis
1%
Neuropathy Peripheral
1%
Muscle Twitching
1%
Musculoskeletal Chest Pain
1%
Partial Seizures
1%
Affect Lability
1%
Post Herpetic Neuralgia
1%
Restless Legs Syndrome
1%
Renal Failure
1%
Psychomotor Retardation
1%
Hallucination, Auditory
1%
Epistaxis
1%
Hallucinations, Mixed
1%
Mania
1%
Eczema
1%
Scar Pain
1%
Skin Irritation
1%
Urticaria
1%
Flushing
100%
80%
60%
40%
20%
0%
Study treatment Arm
Experimental Arm
Standard Arm

MIRAGE Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Experimental ArmExperimental Treatment3 Interventions
Radiotherapy + Temozolomide + Marizomib followed by adjuvant Temozolomide + Marizomib
Group II: Standard ArmActive Control2 Interventions
Radiotherapy + Temozolomide followed by adjuvant Temozolomide
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Marizomib
Not yet FDA approved
Temozolomide
FDA approved
radiotherapy
2007
Completed Phase 4
~3210

Find a Location

Who is running the clinical trial?

European Organisation for Research and Treatment of Cancer - EORTCLead Sponsor
412 Previous Clinical Trials
164,416 Total Patients Enrolled
20 Trials studying Glioblastoma
5,306 Patients Enrolled for Glioblastoma
CelgeneIndustry Sponsor
637 Previous Clinical Trials
128,765 Total Patients Enrolled
10 Trials studying Glioblastoma
1,379 Patients Enrolled for Glioblastoma
Canadian Cancer Trials GroupNETWORK
126 Previous Clinical Trials
67,293 Total Patients Enrolled
2 Trials studying Glioblastoma
577 Patients Enrolled for Glioblastoma

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are we still recruiting people for this clinical trial?

"This particular clinical trial, which was first advertised on July 26th 2018 and last updated on October 5th 2020, is not recruiting patients at the moment. However, there are 679 other active studies that are recruiting."

Answered by AI

Is there precedence for Marizomib in medical research?

"First studied in 2002 at Memorial Sloan Kettering Cancer Center, marizomib has been the subject of 332 completed clinical trials. As of right now, there are 221 active trials, with a significant presence in Québec and Florida."

Answered by AI

To your knowledge, has a study like this been conducted before?

"In total, there are 221 ongoing studies that involve Marizomib in some capacity. These studies are being conducted in 947 different cities and 34 countries. The first study was held in 2002 and was completed in the Phase 2 drug approval stage. Out of the 221 total studies, 332 have been completed thus far."

Answered by AI

Does Marizomib put patients at a high risk for health complications?

"Marizomib's safety is based on clinical data from Phase 3 trials, which means that its efficacy has been tested and its safety has been corroborated multiple times."

Answered by AI

How many patients are being treated as part of this study?

"Unfortunately, this clinical trial is not currently looking for new participants. The trial was first posted on 7/26/2018 and was last edited on 10/5/2020. However, there are 458 other trials for patients with glioblastoma and 221 for Marizomib actively recruiting patients."

Answered by AI

What indications does Marizomib usually treat?

"Marizomib is an effective form of treatment for refractory, advanced mycosis fungoides that has proved resistant to nitrosourea treatment and advance directives."

Answered by AI

Does this research project have more than one site in this state?

"This trial is enrolling patients at 32 sites across Québec, Hamilton and Trois-Rivières. To minimize travel requirements, participants are encouraged to select the site nearest them."

Answered by AI

Who else is applying?

What state do they live in?
California
How old are they?
18 - 65
What site did they apply to?
University of California at Irvine
What portion of applicants met pre-screening criteria?
Did not meet criteria
Recent research and studies
clinicaltrials.govStudy
A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma
2018. "A Phase III Trial of With Marizomib in Patients With Newly Diagnosed Glioblastoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03345095.
~111 spots leftby May 2025
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top