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18F-fluoroestradiol for Endometriosis

Phase 2
Waitlist Available
Led By Jorge Oldan, MD
Research Sponsored by University of North Carolina, Chapel Hill
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up day of scan, up to 2 hours
Awards & highlights

Study Summary

This trial is testing whether a FES PET/MRI scan can detect endometriosis. 12 participants with clinically suspected endometriosis will have the scan before surgery to confirm the diagnosis.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~day of scan, up to 2 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and day of scan, up to 2 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Sensitivity of FES PET/MRI for Evaluating Endometriosis (Percentage of Positive Scans)
Specificity of FES PET/MRI for Evaluating Endometriosis (Percentage of Negative Scans)
Secondary outcome measures
Correlation of the FES PET/MRI Specificity to Conventional MRI
Mean Standard Uptake Values (SUV-max) for 18F-fluoroestradiol PET / MRI

Side effects data

From 2022 Phase 2 trial • 8 Patients • NCT04382911
17%
Fatigue
17%
Change in smell
17%
headache
100%
80%
60%
40%
20%
0%
Study treatment Arm
18F-fluoroestradiol PET / MRI

Trial Design

1Treatment groups
Experimental Treatment
Group I: 18F-fluoroestradiol PET / MRIExperimental Treatment1 Intervention
All enrolled subjects will receive the tracer and then have a PET/MRI scan.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
18F-fluoroestradiol
2020
Completed Phase 2
~10

Find a Location

Who is running the clinical trial?

North Carolina Translational and Clinical Sciences InstituteOTHER
55 Previous Clinical Trials
4,279 Total Patients Enrolled
University of North Carolina, Chapel HillLead Sponsor
1,502 Previous Clinical Trials
4,186,734 Total Patients Enrolled
3 Trials studying Endometriosis
43 Patients Enrolled for Endometriosis
Jorge Oldan, MDPrincipal InvestigatorUniversity of North Carolina, Chapel Hill
3 Previous Clinical Trials
50 Total Patients Enrolled
1 Trials studying Endometriosis
24 Patients Enrolled for Endometriosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Evaluation of Endometriosis With 18F-fluoroestradiol PET / MRI
2020. "Evaluation of Endometriosis With 18F-fluoroestradiol PET / MRI". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04382911.
~2 spots leftby Apr 2025
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