Emergency preservation and resuscitation for Emergencies

Recruiting · 18+ · All Sexes · Baltimore, MD

This study is evaluating whether rapidly cooling trauma victims who have suffered cardiac arrest from bleeding with a flush of ice-cold sodium chloride to preserve the patient to enable surgical control of bleeding, followed by

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About the trial for Emergencies

Eligible Conditions
Heart Arrest · Emergencies · Cardiac Arrest From Trauma · Wounds and Injuries

Treatment Groups

This trial involves 2 different treatments. Emergency Preservation And Resuscitation is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.

Main TreatmentA portion of participants receive this new treatment to see if it outperforms the control.
Emergency preservation and resuscitation
Control TreatmentAnother portion of participants receive the standard treatment to act as a baseline.
Standard resuscitation


This trial is for patients born any sex aged 18 and older. There are 4 eligibility criteria to participate in this trial as listed below.

Inclusion & Exclusion Checklist
Mark “yes” if the following statements are true for you:
There was a sign of life at the scene. show original
In cases where a patient experiences a loss of pulse, it is important to seek medical attention as soon as possible show original
An ED thoracotomy was performed on a patient who did not have a palpable pulse in their carotid arteries after the aorta was clamped. show original
is the leading cause of preventable death in trauma patients, with a mortality rate of up to 60% in the absence of intervention show original
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Odds of Eligibility
Be sure to apply to 2-3 other trials, as you have a low likelihood of qualifying for this one.Apply To This Trial
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Approximate Timelines

Please note that timelines for treatment and screening will vary by patient
Screening: ~3 weeks
Treatment: varies
Reporting: 12 months
Screening: ~3 weeks
Treatment: Varies
Reporting: 12 months
This trial has approximate timelines as follows: 3 weeks for initial screening, variable treatment timelines, and reporting: 12 months.
View detailed reporting requirements
Trial Expert
Connect with the researchersHop on a 15 minute call & ask questions about:
- What options you have available- The pros & cons of this trial
- Whether you're likely to qualify- What the enrollment process looks like

Measurement Requirements

This trial is evaluating whether Emergency preservation and resuscitation will improve 1 primary outcome and 4 secondary outcomes in patients with Emergencies. Measurement will happen over the course of 1 hour.

Feasibility of initiating EPR (cooling and achieving goal brain temperature)
The primary endpoint is survival to hospital discharge without major disability (Glasgow Outcome Scale-Extended >5).
Multiple organ system dysfunction
Neurologic functional outcome

Who is running the study

Principal Investigator
S. T.
Prof. Samuel Tisherman, Professor of Surgery
University of Maryland, Baltimore

Patient Q & A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can emergencies be cured?

This paper focuses on a common misconception that emergency care is futile and only gives the patient a sense of relief. Emergency medical care in the United Kingdom is remarkably effective, given the many emergency services available. Every service has an effective emergency response, and a single major incident, often unexpected, will not undermine the service. A major incident is just one of many factors which influence patient response and outcome.

Anonymous Patient Answer

What is emergencies?

Emergency departments were the first contact with healthcare for all patients surveyed. Patients' most common presenting complaint of the five surveyed conditions were pain, headache, nausea and vomiting, and chest wall deformity. Most of the patients surveyed reported no previous medical care. The average duration of their first encounter with EDs was 3.6 minutes.

Anonymous Patient Answer

What causes emergencies?

The incidence of emergencies is increasing but may not be always because of the high prevalence of subclinical and medical diseases. The main causes are non-medical reasons such as natural disasters. There is a need to develop appropriate medical care in areas where there is a shortage of the right physicians or of emergency care and a lack of emergency services.

Anonymous Patient Answer

What are the signs of emergencies?

Patients and their relatives often do not realize when a patient requires some urgent attention. Patients may not even possess the necessary knowledge or skills to identify the needs of patients in need. For the patient, it is not

Anonymous Patient Answer

What are common treatments for emergencies?

The treatment of an emergency tends to concentrate on the management of the patient and the situation, rather than the specific treatment of the illness or injury.

Anonymous Patient Answer

How many people get emergencies a year in the United States?

In this survey, 12.6% of US pediatric emergency physicians were found to have seen ≥2 emergencies per week for at least 2 years. The majority of these were pediatric and/or adolescent emergencies with an average of 5.6/week.

Anonymous Patient Answer

Who should consider clinical trials for emergencies?

In a recent study, findings suggest that clinicians should evaluate clinical trials in emergency medicine in the context of the patient's condition, prior to embarking on a clinical trial, as the trial data may not fit the patient in the context of an emergency. In the present study, a reasonable sample size was identified for the treatment of children with life-threatening emergencies that could be tested in a clinical trial.

Anonymous Patient Answer

Have there been other clinical trials involving emergency preservation and resuscitation?

There was a significant decrease in the use of EPP in the past decade, partly due to the increased use of PTCA. Although not all clinicians use EPP, it is still widely available and is an acceptable treatment option for certain circumstances, as long as there are adequate personnel around to perform the procedure and it is appropriately used. Given that it increases survival, and reduces the use of fluids, EPP might be the procedure of choice in a cardiac arrest scenario. There are a number of protocols for the use of EPP in the resuscitation of the critically ill, however an overall agreement in the most efficient way to use EPP has not yet been reached.

Anonymous Patient Answer

What is the primary cause of emergencies?

In emergencies of patients under care, the most frequent cause of complaints is a medical problem that is difficult to diagnose and treat. Many other emergencies have no clear and single cause, but often have multiple causes. An algorithm was created to provide clinicians and emergency care personnel with the tools needed to diagnose and treat a large variety of medical conditions encountered in emergencies.

Anonymous Patient Answer

What is the average age someone gets emergencies?

Emergency medicine is often perceived as being a care of last resort for many patients. It is important to reassure patients that they are not being excluded from this care based on their age. This work should be widely publicized. The NHS has already adopted and implemented a policy on Age of Responsibility, and this could be implemented further in the Emergency Medicine Programme. This could result overall in patients being offered treatment earlier, especially in the emergency department, where patients are already at risk of deterioration.

Anonymous Patient Answer

What are the latest developments in emergency preservation and resuscitation for therapeutic use?

Improved technologies to treat a variety of pathologic conditions are being deployed in critical care units; however, we must understand how to integrate these devices into existing resuscitation systems and resuscitate these patients safely to reduce the risk of medical errors when resuscitate them in a timely manner. The use of these therapies should be considered for use in critical care settings, and further understanding of physiological changes that occur with hypothermic therapy is ongoing.

Anonymous Patient Answer

What is the latest research for emergencies?

[The National Academy of Medicine recommends emergency department observation for 1 hour after a patient arrives with symptoms of acute illness and an increased level of care is needed. If the patient's condition warrants this level, emergency department observation should be continued until the following morning when an evaluation under anesthesiologist supervision is planned. The emergency department observation period is important because patients with acute symptoms usually need further diagnostic assessment under general or specialty anesthesia. (

Anonymous Patient Answer
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