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Procedure
EPR for Traumatic Cardiac Arrest (EPR-CAT Trial)
Phase 2
Waitlist Available
Led By Samuel A Tisherman, MD
Research Sponsored by University of Maryland, Baltimore
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 months
Awards & highlights
EPR-CAT Trial Summary
This trial is testing a new method of saving people who have suffered cardiac arrest from bleeding.
Eligible Conditions
- Cardiac Arrest From Trauma
EPR-CAT Trial Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ 12 months
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 months
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Primary outcome measures
The primary endpoint is survival to hospital discharge without major disability (Glasgow Outcome Scale-Extended >5).
Secondary outcome measures
Feasibility of initiating EPR (cooling and achieving goal brain temperature)
Multiple organ system dysfunction
Neurologic functional outcome
+1 moreEPR-CAT Trial Design
2Treatment groups
Experimental Treatment
Active Control
Group I: Emergency preservation and resuscitationExperimental Treatment1 Intervention
These subjects would undergo the complete EPR protocol, including rapid induction of hypothermia, resuscitative surgery, and resuscitation with cardiopulmonary bypass.
Group II: Concurrent controlsActive Control1 Intervention
These subjects would undergo standard resuscitative efforts.
Find a Location
Who is running the clinical trial?
University of Maryland, BaltimoreLead Sponsor
687 Previous Clinical Trials
374,626 Total Patients Enrolled
Cook County HealthOTHER_GOV
46 Previous Clinical Trials
16,175 Total Patients Enrolled
John H. Stroger HospitalOTHER
42 Previous Clinical Trials
13,105 Total Patients Enrolled
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Eligibility Criteria:
This trial includes the following eligibility criteria:- The person showed no signs of life for more than 5 minutes before emergency medical procedures were started.You have a severe injury that is not survivable.You have signs of a serious head injury, like a major change in the shape of your face or head.Your heart has stopped beating.A quick evaluation of the injuries shows severe damage to a lot of body areas or blunt trauma to many parts of the body.You have a serious injury with a lot of bleeding.The person shows signs of life at the scene, like having a pulse, breathing, moving on their own, or reacting to light with their pupils.You didn't have a pulse for less than 5 minutes before reaching the emergency room or while in the emergency room or operating room.If you had emergency chest surgery and did not regain a pulse in the neck arteries right away.
Research Study Groups:
This trial has the following groups:- Group 1: Concurrent controls
- Group 2: Emergency preservation and resuscitation
Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are there any open positions for participants in this research?
"This study, which was active from October 1st 2016 to June 18th 2022 according to clinicaltrials.gov, is no longer seeking patients for participation. There are, however, 1030 other trials that are currently looking for volunteers."
Answered by AI
Is this research study only enrolling patients who are 75 years old or younger?
"The age bracket for eligible patients in this study are individuals that are 18 years old or older, but younger than 65."
Answered by AI
Are there any inherent risks to using Emergency preservation and resuscitation?
"Since this is a Phase 2 trial, meaning that while there are some data supporting safety, there are no data yet supporting efficacy, we have given Emergency preservation and resuscitation a score of 2."
Answered by AI
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