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Nonsteroidal Anti-inflammatory Drug

Aspirin 81 mg for High Blood Pressure

Phase 2

Waitlist Available

Led By Olga Grechukhina, MD

Research Sponsored by Yale University

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up birth until 1 year of age

Awards & highlights

Study Summary

This trial will see if low-dose aspirin can help prevent hypertensive disorders of pregnancy in women with stage 1 hypertension.

Eligible Conditions

High Blood Pressure
Pre-eclampsia

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ birth until 1 year of age

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~birth until 1 year of age

This trial's timeline: 3 weeks for screening, Varies for treatment, and birth until 1 year of age for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Development of Hypertensive Disorder

Secondary outcome measures

Birthweight

Development of Eclampsia

Development of Gestational Hypertension

+10 more

Side effects data

From 2011 Phase 2 & 3 trial • 93 Patients • NCT01586975

Nose bleeds

GI bleeding

Clinical Stroke

100%

80%

60%

40%

20%

Study treatment Arm

Aspirin 81 mg

Aspirin >300 mg

Clopidogrel 75 mg

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: AspirinExperimental Treatment1 Intervention

Participants randomized to 81 mg of Aspirin daily

Group II: PlaceboPlacebo Group1 Intervention

Participants randomized to placebo daily

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Aspirin 81 mg

2007

Completed Phase 4

~810

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Yale UniversityLead Sponsor

1,847 Previous Clinical Trials

2,736,478 Total Patients Enrolled

Olga Grechukhina, MDPrincipal InvestigatorYale University

Hillart Hosier, MDPrincipal InvestigatorYale University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are enrollment slots for this clinical trial currently available?

"Affirmative. The data available on clinicaltrials.gov reveals that this medical study is currently enlisting patients; it was initially published on August 6th 2020 and last revised on November 15th 2021. Approximately 490 individuals will be recruited from a single site."

Answered by AI

What conditions typically warrant a prescription for Aspirin 81 mg?

"Aspirin 81 mg can be employed to manage percutaneous coronary intervention (PCI), treat inflammation, and assist in dental procedures."

Answered by AI

Has the FDA sanctioned Aspirin 81 mg for public use?

"There is some evidence suggesting Aspirin 81 mg's safety, so it received a rating of 2. However, no studies have yet tested the efficacy of this drug."

Answered by AI

What is the highest possible participant count for this clinical experiment?

"Affirmative. Data published on clinicaltrials.gov demonstrate that this medical study, which was initiated on August 6th 2020, is currently recruiting volunteers. Around 490 individuals must be enrolled from 1 centre in total."

Answered by AI

Is this clinical exploration unprecedented in its scope?

"Since 2005, research has been conducted on Aspirin 81 mg. Abbott initiated the original clinical trial in that year, which explored the data of 15480 patients. This medicinal product was later approved during Phase 4 drug trials and currently there are 168 active studies being held across 1398 cities and 57 nations."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)

2020. "Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04402385.