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Salicylic Augmentation for Depression (SAD Trial)
SAD Trial Summary
This trial will test if adding aspirin to antidepressants can help lessen symptoms of depression and if certain people may benefit more than others.
- Depression
- Major Depressive Disorder
SAD Trial Timeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.SAD Trial Design
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Who is running the clinical trial?
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- You have a history of bleeding in your digestive system (like stomach or intestines).You have had a problem with bleeding in the past.You are currently taking oral steroids or other medications that affect your immune system.You are sensitive or allergic to salicylates.You are currently having thoughts about hurting yourself or taking your own life.You have a history of extreme mood swings or experiencing things that aren't real.You currently have a diagnosis of major depressive disorder.You have had problems with alcohol or drugs in the past month.You have had a previous stroke.You are currently taking medication to thin your blood or regularly taking non-steroidal anti-inflammatory drugs (NSAIDs).You have a pre-existing neurological condition that affects your brain and nervous system.You have another medical condition that affects your immune system.
- Group 1: Placebo augmentation to treatment
- Group 2: Aspirin augmentation to treatment
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- Approved for 10 Other Conditions - This treatment demonstrated efficacy for 10 other conditions.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
When is Aspirin augmentation to treatment most effective?
"By augmenting traditional treatments with Aspirin, it is possible to effectively manage pain, dermatitis, and myocardial infarction."
Are patients of all ages eligible for this experiment?
"The clinical trial's eligibility requirements state that patients must be aged 18-65. There are currently 443 trials underway for minors and 1673 separate trials being conducted with elderly patients."
Are people currently being accepted into this test program?
"The trial, which was first advertised on November 15th 2018, is looking for volunteers according to the latest information available from clinicaltrials.gov. The site was last updated on July 29th 2021."
To what degree does Aspirin improve patient outcomes when used in conjunction with other treatments?
"While there is some evidence that Aspirin augmentation to treatment is safe, it remains unproven if the intervention is effective. Our team has rated its safety a 2."
Who would be most benefited by participating in this clinical trial?
"Up to 74 individuals that are experiencing melancholia and meet the age requirement of 18-65 years old may be admitted into this study. The key inclusion criteria are as follows: a stable treatment history in the past 8 weeks with no changes in medication or psychotherapy, women of childbearing age must agree to use contraception during the trial, a current diagnosis of major depressive disorder, an HDRS score >19, failed antidepressant trials in the past, or a combination of 1 antidepressant and 1 augmentation agent."
Has there been any research like this before?
"As of right now, there are 182 independent Aspirin augmentation to treatment trials being conducted in 61 countries and 1451 cities. The very first trial was all the way back in 2002 and it completed its Phase 3 drug approval stage that year. Since then, 689 more studies have been finished."
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