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Neuraminidase Inhibitor

Zanamivir for Type 2 Diabetes (NAED Trial)

Phase 2
Waitlist Available
Led By Luis Martinez-Lemus, PhD
Research Sponsored by University of Missouri-Columbia
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Diagnosis of T2D classified based on physician diagnosis
Men and women with a BMI of 25-39 kg/m2
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 0 and 5 days
Awards & highlights

NAED Trial Summary

This trial is testing whether the drug zanamivir can help improve the function of blood vessels in people with type 2 diabetes.

Who is the study for?
This trial is for adults aged 45-64 with Type 2 Diabetes, a BMI of 25-39 kg/m2, and no severe health issues like active cancer or heart disease. It's not for pregnant women, smokers, those with allergies to lactose or milk proteins, heavy drinkers, or people on certain medications.Check my eligibility
What is being tested?
The study tests if Zanamivir can improve blood vessel function in Type 2 Diabetes patients. Participants will receive Zanamivir to see if it helps their condition by inhibiting neuraminidase activity.See study design
What are the potential side effects?
Zanamivir may cause side effects such as headaches, nausea, diarrhea, bronchitis-like symptoms (coughing and trouble breathing), ear/nose/throat infections; however specific risks related to this trial are not detailed.

NAED Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I have been diagnosed with type 2 diabetes by a doctor.
Select...
My BMI is between 25 and 39.
Select...
I am between 45 and 64 years old.

NAED Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~0 and 5 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 0 and 5 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in glycocalyx integrity
Secondary outcome measures
Change in Vascular function

Side effects data

From 2009 Phase 3 trial • 64 Patients • NCT00784784
10%
pneumonia
100%
80%
60%
40%
20%
0%
Study treatment Arm
Influenza Vaccine
Antiviral Prophylaxis

NAED Trial Design

1Treatment groups
Experimental Treatment
Group I: Zanamivir treatmentExperimental Treatment1 Intervention
Study participants will receive 5 days of treatment with a zanamivir inhaler.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Zanamivir
2009
Completed Phase 3
~1050

Find a Location

Who is running the clinical trial?

University of Missouri-ColumbiaLead Sponsor
362 Previous Clinical Trials
628,100 Total Patients Enrolled
Luis Martinez-Lemus, PhDPrincipal InvestigatorUniversity of Missouri, School of Medicine

Media Library

Zanamivir (Neuraminidase Inhibitor) Clinical Trial Eligibility Overview. Trial Name: NCT04867707 — Phase 2
Type 2 Diabetes Research Study Groups: Zanamivir treatment
Type 2 Diabetes Clinical Trial 2023: Zanamivir Highlights & Side Effects. Trial Name: NCT04867707 — Phase 2
Zanamivir (Neuraminidase Inhibitor) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04867707 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What demographic is most suitable for inclusion in this clinical trial?

"This clinical trial is searching for 20 individuals aged 45-64, who have been clinically diagnosed with diabetes mellitus type 2. In addition to the age criteria, candidates must not belong to a vulnerable population (e.g., pregnant women or prisoners), have a BMI of 25-39 kg/m2 and be both male and female at randomization."

Answered by AI

Is this trial open to adults who are 18 or older?

"Patients laying within the age range of 45 to 64 are able to participate in this medical trial. Meanwhile, there are 195 trials that cater especially for those below 18 years old and 1066 specifically designed for seniors above 65 year olds."

Answered by AI

Is Zanamivir a reliable treatment option with minimal risk?

"Data collected from Phase 2 trials indicates that zanamivir is a fairly safe medication, scoring it a 2 on our assessment scale. However, efficacy remains unsubstantiated at this point in time."

Answered by AI

Has Zanamivir been explored in other scientific investigations?

"Currently, three investigations are utilizing zanamivir with none in Phase 3. A majority of the trials for this medication take place in Columbia, Missouri but there are seven other sites conducting research as well."

Answered by AI

Are there any opportunities right now to join this research study?

"Data found on clinicaltrials.gov confirms that this study is currently seeking participants, having been first posted on July 14th 2021 and revised most recently on June 6th 2022."

Answered by AI

How many individuals have joined the experiment thus far?

"Assent. According to information presented on clinicaltrials.gov, this experiment is currently enrolling subjects and was initially posted on July 14th 2021. The most recent update was made June 6th 2022 and the study requires 20 volunteers at one site location."

Answered by AI

Who else is applying?

What state do they live in?
Missouri
What site did they apply to?
University of Missouri, School of Medicine Clinical Research Center
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
3+

Why did patients apply to this trial?

Want to improve my diabetes.
PatientReceived 2+ prior treatments

What questions have other patients asked about this trial?

How many times do I need to come in ?
PatientReceived 2+ prior treatments
~3 spots leftby Apr 2025