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Glucagon-like peptide agonist

Liraglutide for Type 1 Diabetes

UBMD Pediatrics, Division of Pediatric Endocrinology, Buffalo, NY
LiraglutidePhase 3Waitlist AvailableLed by Lucy D Mastrandrea, MD, PhDResearch Sponsored by University at Buffalo

Study Summary

This trial will test the effect of liraglutide, a long-acting glucagon-like peptide-1 analog, on blood sugar control in adolescents with Type 1 diabetes. Liraglutide is already approved for the treatment of Type 2 diabetes in adults.

Eligible Conditions
  • Type 1 Diabetes

Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~2 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 2 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mean weekly blood glucose
Secondary outcome measures
Total Daily insulin dose
Other outcome measures
Amylase level
Blood sugar < 70 mg/dL

Side effects data

From 2017 Phase 4 trial • 100 Patients • NCT02014740
29%
nausea
100%
80%
60%
40%
20%
0%
Study treatment Arm
Liraglutide
Metformin

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Pivotal Trial
The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Liraglutide 0.6 mgExperimental Treatment1 Intervention
Liraglutide 0.6 mg daily injection x 7 days
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Liraglutide
FDA approved

Find a site

Who is running the clinical trial?

University at BuffaloLead Sponsor
127 Previous Clinical Trials
93,769 Total Patients Enrolled
Lucy D Mastrandrea, MD, PhDPrincipal Investigator
University at Buffalo

Media Library

Liraglutide (Glucagon-like peptide agonist) Clinical Trial Eligibility Overview. Trial Name: NCT02516657 — Phase 3
Type 1 Diabetes Research Study Groups: Liraglutide 0.6 mg
Type 1 Diabetes Clinical Trial 2023: Liraglutide Highlights & Side Effects. Trial Name: NCT02516657 — Phase 3
Liraglutide (Glucagon-like peptide agonist) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02516657 — Phase 3

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are elderly individuals welcome to participate in this research?

"People who wish to apply for this trial must be aged between 15 and 21. Out of the 1223 similar trials, this is one of the few that includes people in this age range."

Answered by AI

Are we still able to enroll patients in this research project?

"The clinical trial in question is not recruiting patients at this time, according to the information found on clinicaltrials.gov. This study was originally posted on 2012-05-01, and was last updated on 2022-03-07. Although this study is not searching for patients at this time, there are 1344 other studies actively looking for participants at this time."

Answered by AI

Has Liraglutide been accepted by the FDA as a treatment option?

"Liraglutide has been through multiple rounds of clinical trials, so its safety has been well-documented. Our team gives it a score of 3."

Answered by AI

What Liraglutide's common applications in medical treatment?

"Although often used as an exercise treatment, liraglutide can also help patients that have inadequate control on monotherapy, cardiovascular risk reduction, and cardiovascular disease (cvd)."

Answered by AI

Might I be able to help out with this research project?

"This clinical trial is admitting 5 adolescent patients that have been diagnosed with type 1 diabetes mellitus for over a year. These individuals must also be currently using a continuous subcutaneous insulin infusion with continuous glucose monitoring device and have an HbA1c <10%."

Answered by AI

How many subjects are being observed in this experiment?

"As of right now, this study is no longer looking for patients that match the given criteria. The study was first posted on 2012-05-01 and was last updated on 2022-03-07. However, there are presently 1308 studies actively recruiting patients with type 1 diabetes mellitus and 36 studies for Liraglutide that are still searching for participants."

Answered by AI
Recent research and studies
clinicaltrials.govStudy
Liraglutide in Adolescents With Type 1 Diabetes
Lucy D. Mastrandrea 2012. "Liraglutide in Adolescents With Type 1 Diabetes". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02516657.
~0 spots leftby Dec 2023
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