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Serotonin-Norepinephrine Reuptake Inhibitor

Duloxetine for Depression

Phase 3
Waitlist Available
Research Sponsored by University of Utah
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be between 18 and 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 10 weeks
Awards & highlights

Study Summary

This trial is testing if treatments for depression are associated with changes in the endogenous opioid system.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~10 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 10 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
depression score
mu-opioid receptor binding capacity

Side effects data

From 2012 Phase 4 trial • 291 Patients • NCT01118780
11%
Nausea
11%
Headache
9%
Constipation
8%
Dizziness
7%
Dry mouth
6%
Somnolence
5%
Diarrhoea
4%
Abdominal pain upper
4%
Fall
4%
Decreased appetite
4%
Pruritus
3%
Vertigo
3%
Hyperhidrosis
2%
Nasopharyngitis
1%
Hypertensive crisis
1%
Angina pectoris
1%
Back pain
1%
Insomnia
1%
Large intestinal obstruction
100%
80%
60%
40%
20%
0%
Study treatment Arm
Duloxetine
Placebo

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: InterventionalExperimental Treatment1 Intervention
10 weeks of duloxetine beginning at 30 mg per day for week 1, then 60 mg / day thereafter.
Group II: PlaceboPlacebo Group1 Intervention
10 weeks of placebo once daily for 1 week, then twice daily therafter.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Duloxetine
FDA approved

Find a Location

Who is running the clinical trial?

University of UtahLead Sponsor
1,099 Previous Clinical Trials
1,778,689 Total Patients Enrolled
24 Trials studying Depression
2,417 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many human subjects are enrolled in this experiment?

"This study is not presently recruiting candidates at this time. The trial was initially posted on 11/1/2021 and was most recently edited on 4/21/2021. If you are searching for other studies, 865 clinical trials for melancholia and 26 trials for Duloxetine are actively recruiting participants ."

Answered by AI

How do I qualify to take part in this research?

"This study requires 80 individuals who suffer from melancholia and fit the following age, medication, and handedness criteria: 18 - 55 years old; no new treatments during the clinical trial; unmedicated for at least 10 half-lives of the previous AD used; right handed."

Answered by AI

What other research has been published on Duloxetine's effects?

"Duloxetine, an investigational medication, is being trialled in 26 different studies. 4 of these are large-scale Phase 3 trials. Not limited to Redwood City, California, there are 786 hospitals and medical facilities conducting clinical trials for Duloxetine across the world."

Answered by AI

Has Duloxetine undergone FDA approval process?

"Duloxetine has received a safety score of 3. This is because it is a Phase 3 medication, suggesting that not only is there some evidence for its efficacy, but also that there are multiple rounds of data supporting its safety."

Answered by AI

What are some of the primary conditions that Duloxetine is used to treat?

"Duloxetine can be used as an intervention for patients experiencing diabetic peripheral neuropathy, major depressive disorder, and pain in the knee."

Answered by AI

Does this experiment have an upper age limit for participants?

"This particular clinical trial only enrolls patients that are between 18-55 years old. In contrast, there are 113 trials for minors and 633 for senior citizens."

Answered by AI

Are researchers still looking for volunteers for this drug trial?

"This trial is not recruiting at the moment. The listing was created on November 1st, 2021 and last updated on April 21st, 2021. For patients looking for similar studies, there are 865 trials actively enrolling participants with melancholia and 26 trials for Duloxetine currently searching for candidates."

Answered by AI
~0 spots leftby Apr 2025