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Probiotic

Probiotics for Anxiety

Phase 2
Waitlist Available
Led By Dr. Susan Potter, PhD
Research Sponsored by Acadia University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up administered at 10 weeks
Awards & highlights

Study Summary

The proposed project will investigate the effects of probiotics on anxiety and associated psychological and physiological factors in humans. The therapeutic potential of probiotics for reducing anxiety and other factors associated with a disrupted microbiome will be assessed in a double-blind placebo-crossover design. Based on the research findings to date, it is hypothesized that probiotics will reduce anxiety and depressive symptoms.

Eligible Conditions
  • Anxiety
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline (at first meeting)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (at first meeting) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Anxiety Sensitivity Index (ASI) - Time 1 (we are assessing change over time)
Anxiety Sensitivity Index (ASI) - Time 2 (we are assessing change over time)
Anxiety Sensitivity Index (ASI) - Time 3 (we are assessing change over time)
+3 more

Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: ProbioticsActive Control1 Intervention
400mg probiotic capsule taken once daily for ten weeks
Group II: Placebo (rice flour)Placebo Group1 Intervention
400mg placebo capsule containing rice flour taken once daily for ten weeks

Find a Location

Who is running the clinical trial?

Acadia UniversityLead Sponsor
1 Previous Clinical Trials
100 Total Patients Enrolled
1 Trials studying Anxiety
100 Patients Enrolled for Anxiety
Dr. Susan Potter, PhDPrincipal InvestigatorAcadia University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
Proceedings of the National Academy of SciencesJournal
Delivery Mode Shapes the Acquisition and Structure of the Initial Microbiota Across Multiple Body Habitats in Newborns
Dominguez-Bello, Maria G., Elizabeth K. Costello, Monica Contreras, Magda Magris, Glida Hidalgo, Noah Fierer, and Rob Knight. 2010. “Delivery Mode Shapes the Acquisition and Structure of the Initial Microbiota Across Multiple Body Habitats in Newborns”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1002601107.
ScienceJournal
Interactions Between the Microbiota and the Immune System
Hooper, Lora V., Dan R. Littman, and Andrew J. Macpherson. 2012. “Interactions Between the Microbiota and the Immune System”. Science. American Association for the Advancement of Science (AAAS). doi:10.1126/science.1223490.
Brain, Behavior, and ImmunityJournal
Mood and Gut Feelings
Forsythe, Paul, Nobuyuki Sudo, Timothy Dinan, Valerie H. Taylor, and John Bienenstock. 2010. “Mood and Gut Feelings”. Brain, Behavior, and Immunity. Elsevier BV. doi:10.1016/j.bbi.2009.05.058.
lactobacillusJournal
Ingestion of <i>lactobacillus</i> Strain Regulates Emotional Behavior and Central GABA Receptor Expression in a Mouse via the Vagus Nerve
Bravo, Javier A., Paul Forsythe, Marianne V. Chew, Emily Escaravage, Hélène M. Savignac, Timothy G. Dinan, John Bienenstock, and John F. Cryan. 2011. “Ingestion of lactobacillus Strain Regulates Emotional Behavior and Central GABA Receptor Expression in a Mouse via the Vagus Nerve”. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. doi:10.1073/pnas.1102999108.
All > Anxiety > Microbiome
~6 spots leftby Apr 2025
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