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NMDA-antagonist

Nitrous Oxide for Depression

Phase 2
Recruiting
Led By Paul Myles, MD
Research Sponsored by Bayside Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up at 24 hours
Awards & highlights

Study Summary

This trialis researching if nitrous oxide can be used to reduce symptoms of Major Depressive Disorder (MDD). A single dose of nitrous oxide may have a fast and long-lasting effect and is safer to administer than other alternatives.

Eligible Conditions
  • Depression

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~at 24 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and at 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in HDRS-21 score
Secondary outcome measures
Computerized Adaptive Test-Depression Inventory (CAT-DI)
Computerized Adaptive Test-Suicide Scale (CAT-SS)
Dose effect of nitrous oxide using treatment-by-dose interaction term in a logistic regression model
+5 more
Other outcome measures
Adverse events

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Nitrous Oxide 50% or 25%Experimental Treatment1 Intervention
Nitrous oxide at an inhaled concentration of 50% or 25%
Group II: PlaceboPlacebo Group1 Intervention
Oxygen-air mixture
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Nitrous oxide
FDA approved

Find a Location

Who is running the clinical trial?

Bayside HealthLead Sponsor
111 Previous Clinical Trials
35,674 Total Patients Enrolled
5 Trials studying Depression
318 Patients Enrolled for Depression
Paul Myles, MDPrincipal InvestigatorThe Alfred
1 Previous Clinical Trials
172 Total Patients Enrolled
1 Trials studying Depression
172 Patients Enrolled for Depression

Media Library

Nitrous Oxide (NMDA-antagonist) Clinical Trial Eligibility Overview. Trial Name: NCT03869736 — Phase 2
Depression Research Study Groups: Nitrous Oxide 50% or 25%, Placebo
Depression Clinical Trial 2023: Nitrous Oxide Highlights & Side Effects. Trial Name: NCT03869736 — Phase 2
Nitrous Oxide (NMDA-antagonist) 2023 Treatment Timeline for Medical Study. Trial Name: NCT03869736 — Phase 2
Depression Patient Testimony for trial: Trial Name: NCT03869736 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is there still room for participants to join this research endeavor?

"According to records hosted on clinicaltrials.gov, this medical trial is not presently open for recruitment. The study's first listing was published January 22nd 2019 and last updated April 20th 2020; however, there are an abundance of other trials enrolling patients at the moment (1991)."

Answered by AI

What research has been conducted regarding the application of Nitrous Oxide at either 50% or 25% concentrations?

"Presently, 13 clinical trials researching Nitrous Oxide 50% or 25%, with 1 of them in Phase 3, are underway. The majority of these investigations are based in Saint Louis, Missouri and there is a total of 14 locations running the relevant tests."

Answered by AI

To what degree would Nitrous Oxide 50% or 25% put patients at risk?

"Our team has evaluated Nitrous Oxide 50% and 25%, giving it a score of 2 on our scale due to the lack of evidence attesting to its efficacy, though there is some data that points towards safety."

Answered by AI

What is the scope of participants for this research endeavor?

"At this juncture, this clinical trial does not have open positions. The listing first appeared in January 2019 and the data was last modified on April 2020. If you're searching for other trials, there are presently 1978 studies that accept people with depression and 13 trails featuring Nitrous Oxide 50% or 25% actively admitting new participants."

Answered by AI

Who else is applying?

What state do they live in?
Illinois
What portion of applicants met pre-screening criteria?
Met criteria
How many prior treatments have patients received?
0

Why did patients apply to this trial?

I like visiting university of Chicago and I like to experiment with other solutions for my depression rather than always pills.
PatientReceived 2+ prior treatments
Recent research and studies
clinicaltrials.govStudy
Nitrous Oxide for the Treatment of Major Depressive Disorder
2019. "Nitrous Oxide for the Treatment of Major Depressive Disorder". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03869736.
All > Mdd
~28 spots leftby Apr 2025
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