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Treatment for Cystic Fibrosis (PIPE Trial)

Phase 3

Waitlist Available

Research Sponsored by The Hospital for Sick Children

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 1 year follow up time

Awards & highlights

PIPE Trial Summary

This trial will test whether adding prednisone to the standard IV antibiotic treatment for CF pulmonary exacerbations can help patients recover their lung function more quickly.

Eligible Conditions

Cystic Fibrosis Pulmonary Exacerbation

PIPE Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 1 year follow up time

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~1 year follow up time

This trial's timeline: 3 weeks for screening, Varies for treatment, and 1 year follow up time for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Lung function recovery

Secondary outcome measures

Duration of antibiotic treatment

change in pulmonary function testing

change in serum inflammatory markers

+7 more

PIPE Trial Design

2Treatment groups

Active Control

Group I: PlaceboActive Control1 Intervention

Placebo

Group II: TreatmentActive Control1 Intervention

Prednisone

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

The Hospital for Sick ChildrenLead Sponsor

689 Previous Clinical Trials

6,945,345 Total Patients Enrolled

23 Trials studying Cystic Fibrosis

2,078 Patients Enrolled for Cystic Fibrosis

Canadian Cystic Fibrosis FoundationOTHER

6 Previous Clinical Trials

446 Total Patients Enrolled

6 Trials studying Cystic Fibrosis

446 Patients Enrolled for Cystic Fibrosis

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are the findings of this research unique, or have similar treatments been looked into before?

"Hulston Cancer Center at Cox Medical Center South was the first to study this intervention in 2001. 833 studies have completed since then. Right now, there are 338 clinical trials underway, a significant number of which are based out of Calgary, Alberta."

Answered by AI

What are the main indications for this therapy?

"This treatment is commonly used to help manage thyroiditis. However, it has also been shown to be effective for other conditions such as ulcerative colitis, malignant neoplasms, and varicella-zoster virus acute retinal necrosis."

Answered by AI

How many different hospitals are managing this clinical trial?

"In addition to The Governers of The University of Calgary - Alberta Health Services in Calgary, Alberta, University of Saskatchewan - Saskatchewan Health Authority in Saskatoon, Saskatchewan, and British Columbia Children's Hospital in Vancouver, British Columbia, this trial is also being held at 12 other locations."

Answered by AI

How many study participants will be recruited for this clinical trial?

"That is correct. The trial, which began recruiting on May 1st, 2017, is still looking for 84 individuals to participate. There are 12 sites where the trial is taking place."

Answered by AI

Does the FDA support this type of medication?

"The safety of this treatment was deemed a 3 by our team at Power. This is because the trial is currently in Phase 3, which suggests that there is both evidence of efficacy and multiple rounds of data supporting safety."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Prednisone in Cystic Fibrosis Pulmonary Exacerbations

Valerie Waters 2017. "Prednisone in Cystic Fibrosis Pulmonary Exacerbations". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03070522.