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Virus Vaccine

AZD1222 for COVID-19

Phase 3

Waitlist Available

Led By Ann Falsey, MD

Research Sponsored by AstraZeneca

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline (day 1) and days 15, 29, 43, 57, 90, 180, 360, and 730

Awards & highlights

Study Summary

This trial is testing a vaccine to see if it is safe and effective at preventing COVID-19.

Eligible Conditions

COVID-19
Coronavirus

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ baseline (day 1) and days 15, 29, 43, 57, 90, 180, 360, and 730

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~baseline (day 1) and days 15, 29, 43, 57, 90, 180, 360, and 730

This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline (day 1) and days 15, 29, 43, 57, 90, 180, 360, and 730 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of Participants With Adverse Events (AEs) Post Each Dose of Study Intervention

Number of Participants With Binary Response

Number of Participants With Local and Systemic Solicited AEs in the Substudy Only

+1 more

Secondary outcome measures

GMFR for SARS-CoV-2 Neutralizing Antibodies as Measured by Pseudo-neutralization Assay

Severe Acute Respiratory Syndrome

Geometric Mean Fold Rise (GMFR) for SARS-CoV-2 S and RBD Antibodies as Measured by MSD Serology Assay

+11 more

Side effects data

From 2023 Phase 3 trial • 32450 Patients • NCT04516746

29%

COVID-19

17%

Injection site pain

16%

Headache

13%

Fatigue

10%

Chills

Pain

Myalgia

Pyrexia

Body temperature increased

Diarrhoea

Cough

Rhinorrhoea

Injection related reaction

Oropharyngeal pain

Nasal congestion

Nausea

Pain in extremity

Reactogenicity event

Arthralgia

100%

80%

60%

40%

20%

Study treatment Arm

AZD1222

Placebo

Trial Design

2Treatment groups

Experimental Treatment

Placebo Group

Group I: AZD1222Experimental Treatment1 Intervention

Approximately 20,000 participants randomized to the AZD1222 arm

Group II: PlaceboPlacebo Group1 Intervention

Approximately 10,000 participants randomized to the saline placebo arm

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

AZD1222

2020

Completed Phase 4

~5441700

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

AstraZenecaLead Sponsor

4,267 Previous Clinical Trials

288,574,531 Total Patients Enrolled

52 Trials studying COVID-19

256,165,072 Patients Enrolled for COVID-19

Iqvia Pty LtdIndustry Sponsor

107 Previous Clinical Trials

137,618 Total Patients Enrolled

7 Trials studying COVID-19

67,819 Patients Enrolled for COVID-19

Ann Falsey, MDPrincipal InvestigatorUniversity of Rochester

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the age limit for this experiment older than 40 years old?

"The age requirements to enroll in this trial are that participants must be over 18 and under 130."

Answered by AI

Could I be included as a subject in this research?

"The current clinical trial is investigating a potential treatment for covid-19 and patients should meet the following two qualifications: be between 18-130 years old and have a positive diagnosis for covid-19. The trial will be admitting around 32459 people in total."

Answered by AI

How many people are filling out the paperwork to be a part of this experiment?

"This study is no longer looking for participants. It was originally posted on August 28th, 2020 and the last update was on October 6th, 2020. There are 1150 other studies currently enrolling patients with covid-19 and 12 for AZD1222 if you are interested in participating in other trials."

Answered by AI

How many lenalidomide clinical trials are underway currently?

"Currently, this clinical trial is being conducted at 75 different sites. These locations include Fort Sam Houston, Fargo, The Woodlands and other cities. If you are considering enrolling, it might be best to choose a location near to reduce travel time and costs."

Answered by AI

Can you please tell me about other times when AZD1222 was used in research?

"As of now, there are a total of 12 clinical trials ongoing for AZD1222. Out of these, 3 trials are in Phase 3. The majority of these studies are based in Seattle, Washington; however, there are a total of 205 locations running trials for AZD1222."

Answered by AI