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CloSYS Ultra Sensitive Rinse mouthwash for Viral Diseases (AMPoL Trial)

Phase 2
Waitlist Available
Led By Stuart A Gansky, DrPH
Research Sponsored by University of California, San Francisco
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Tested positive for COVID-19 with a sample collected in the prior 7 days
Ability to read and speak English or Spanish
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline to 3 months
Awards & highlights

AMPoL Trial Summary

This trial will test the safety and effectiveness of different mouthwashes on people with COVID-19.

Eligible Conditions
  • Viral Diseases
  • COVID-19
  • Coronavirus
  • Pharyngitis

AMPoL Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

AMPoL Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline to 3 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline to 3 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in SARS-CoV-2 Viral Load
Secondary outcome measures
Any Hospitalization(s)
Self-reported Clinical Symptom(s)
Other outcome measures
Any Hospitalization(s) in Tobacco Users, Marijuana Smokers, or Vapers
Change in SARS-Cov-2 Viral Load in Tobacco Users, Marijuana Smokers, or Vapers
Change in Self-reported Clinical Symptom Onset in Tobacco Users, Marijuana Smokers, or Vapers

AMPoL Trial Design

5Treatment groups
Experimental Treatment
Placebo Group
Group I: Oral-B Mouth Sore (H2O2) mouthwashExperimental Treatment1 Intervention
Over the counter: Oral-B Mouth Sore (Oral-B, USA) contains hydrogen peroxide (H2O2)
Group II: Listerine MouthwashExperimental Treatment1 Intervention
Over the counter: Listerine Zero (Alcohol-Free)(Johnson and Johnson, USA) (C30H52O3)
Group III: Crest Pro-Health Multi-Protection (C21H38ClN) mouthwashExperimental Treatment1 Intervention
Over the counter: Crest Pro-Health Multi-Protection (Crest, USA) contains cetylpyridinium chloride (C21H38ClN)
Group IV: CloSYS (ClO2) mouthwashExperimental Treatment1 Intervention
Over the counter: CloSYS Ultra Sensitive Rinse (Rowpar Pharmaceutical Inc., USA) contains stabilized chlorine dioxide (ClO2)
Group V: Control (Distilled Water)Placebo Group1 Intervention
Over the counter: Distilled water

Find a Location

Who is running the clinical trial?

University of California, San FranciscoLead Sponsor
2,498 Previous Clinical Trials
11,936,294 Total Patients Enrolled
Rowpar Pharmaceuticals, Inc.Industry Sponsor
4 Previous Clinical Trials
316 Total Patients Enrolled
Stuart A Gansky, DrPHPrincipal InvestigatorProfessor and Lee Hysan Chair of Oral Epidemiology
2 Previous Clinical Trials
397 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
The Journal of Infectious DiseasesJournal
Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2
Meister, Toni Luise, Yannick Brüggemann, Daniel Todt, Carina Conzelmann, Janis A Müller, Rüdiger Groß, Jan Münch, et al.. 2020. “Virucidal Efficacy of Different Oral Rinses Against Severe Acute Respiratory Syndrome Coronavirus 2”. The Journal of Infectious Diseases. Oxford University Press (OUP). doi:10.1093/infdis/jiaa471.
BMC Health Services ResearchJournal
Cost-effectiveness of Gargling for the Prevention of Upper Respiratory Tract Infections
Sakai, Michi, the Great Cold Investigators-I, Takuro Shimbo, Kazumi Omata, Yoshimitsu Takahashi, Kazunari Satomura, Tetsuhisa Kitamura, et al.. 2008. “Cost-effectiveness of Gargling for the Prevention of Upper Respiratory Tract Infections”. BMC Health Services Research. Springer Science and Business Media LLC. doi:10.1186/1472-6963-8-258.
Journal of PeriodontologyJournal
Evaluation of Ultrasonic Scaling Unit Waterline Contamination After Use of Chlorine Dioxide Mouthrinse Lavage
Wirthlin, M. Robert, and Grayson W. Marshall Jr.. 2001. “Evaluation of Ultrasonic Scaling Unit Waterline Contamination After Use of Chlorine Dioxide Mouthrinse Lavage”. Journal of Periodontology. Wiley. doi:10.1902/jop.2001.72.3.401.
The International Journal of ProsthodonticsJournal
Clinical Evaluation of Chlorine Dioxide for Disinfection of Dental Instruments
Watamoto, Takao, Hiroshi Egusa, Takashi Sawase, and Hirofumi Yatani. 2013. “Clinical Evaluation of Chlorine Dioxide for Disinfection of Dental Instruments”. The International Journal of Prosthodontics. Quintessence Publishing. doi:10.11607/ijp.3465.
~13 spots leftby Apr 2025
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