GSE and Xylitol for Covid19

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Larkin Community Hospital Palm Springs Campus, Miami, FL
Covid19+1 More
GSE and Xylitol - Other
Eligibility
18+
All Sexes
Eligible conditions
Select

Study Summary

This study is evaluating whether a combination of grape seed extract and xylitol may help reduce the time it takes for a person to become negative for the common cold virus. original:

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Eligible Conditions

  • Covid19

Treatment Effectiveness

Effectiveness Progress

2 of 3
This is further along than 85% of similar trials

Other trials for Covid19

Study Objectives

This trial is evaluating whether GSE and Xylitol will improve 1 primary outcome in patients with Covid19. Measurement will happen over the course of Baseline and 7 days.

Baseline and 7 days
Change of time to negativisation via PCR

Trial Safety

Safety Progress

3 of 3
This is further along than 85% of similar trials

Other trials for Covid19

Trial Design

3 Treatment Groups

Treatment Group
1 of 3
Control
1 of 3
Control placebo
1 of 3
Experimental Treatment
Non-Treatment Group

This trial requires 250 total participants across 3 different treatment groups

This trial involves 3 different treatments. GSE And Xylitol is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.

Treatment Group
Other
Xylitol + GSE
ControlSaline
Control placebo
Drug
Saline

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: baseline and 7 days
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly baseline and 7 days for reporting.

Who is running the study

Principal Investigator
G. F. M.
Gustavo Ferrer M.D., Principal Investigator
Larkin Community Hospital

Closest Location

Larkin Community Hospital Palm Springs Campus - Miami, FL

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 5 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Adults of ages 18 to 90 years of both sexes
With positive SARS-CoV-2 carriage confirmed by nasopharyngeal PCR
Signed informed consent
1- Mild symptoms: Minimum respiratory symptoms or asymptomatic plus positive test
2- Moderate symptoms: Respiratory symptoms such as cough, mild shortness of breath with mild oxygen desaturation(room air SpO2 <92% and >88% or <88% corrected to >92% with 2lt of oxygen)

Patient Q&A Section

What is covid-19?

"Covid-19 is an infection transmitted by a virus in the family "Coronaviridae"; this family includes pathogens such as the common cold. The disease was first identified in Wuhan, China, during the 19th century. Despite the high mortality associated with the virus, it is not as deadly as some other viral diseases such as HIV and influenza. Although the virus can affect any age group, it is mostly seen in infants and young adults which may be associated with socioeconomic situations and economic challenges." - Anonymous Online Contributor

Unverified Answer

How many people get covid-19 a year in the United States?

"We estimate that about 1 in 12 American adults is a case of symptomatic infection of COVID-19 during a year. However, some states are far below this rate of illness. Efforts to reduce this rate are likely necessary to mitigate the health effects of the epidemic and could be accomplished in a number of ways." - Anonymous Online Contributor

Unverified Answer

What are the signs of covid-19?

"Most sufferers of coronavirus pneumonia will recover within a month. About 8% will develop severe complications such as acute respiratory distress syndrome and required hospitalisation. In those with underlying disease, the virus may disseminate and cause other complications, including acute interstitial pneumonia and an increased mortality rate. The signs observed in the early period of infection include fatigue, shortness of breath and a fever above 38 degrees Celsius if no previous flu symptoms. There will be a wide span in the days between the onset and the presentation of the cough and fever. Symptoms include a heaviness of the chest, shortness of breath and flu-like symptoms that can include fever, lethargy, headaches, nausea, vomiting and sweating." - Anonymous Online Contributor

Unverified Answer

What are common treatments for covid-19?

"The following treatments with proven clinical effectiveness have been observed to be commonly used for treatment of and/or prevention from Covid-19 in the community.\n\n- Analgesics such as non-steroidal anti-inflammatories (NSAIDS) such as ibuprofen\n- anti-allergy medications such as steroid nasal sprays and antihistamine nasal spray." - Anonymous Online Contributor

Unverified Answer

What causes covid-19?

"A new coronavirus is the cause of human coronavirus infection. In the context of a pandemic like the one the world is having, testing for the virus and its antibodies is crucial in determining how to best manage the disease and avoid serious medical issues." - Anonymous Online Contributor

Unverified Answer

Can covid-19 be cured?

"There is no cure for covid-19, but there are treatments available, and the benefits of treatment and the length of disease and the possible consequences and disabilities to the person should be considered before committing. There are currently two different treatment patterns for people with confirmed covid-19: the first is supportive care and the second is symptomatic treatment (such as using oral medications or a breathing aid, etc). Some of the medications used are commonly used for influenza, and as such should be treated on a case-by-case basis. Another option is to treat with the influenza vaccine (as it has been shown to provide partial protection, and may also inhibit the replication of the virus)." - Anonymous Online Contributor

Unverified Answer

What does gse and xylitol usually treat?

"The authors reported the positive short-term outcomes of XIG treatment with regard to disease stability, symptoms, and quality of life. The authors also analyzed the limitations of the current review and the implication for future clinical trials on XIG with regard to possible use in different stages of SARS disease and/or as a possible treatment option." - Anonymous Online Contributor

Unverified Answer

What are the latest developments in gse and xylitol for therapeutic use?

"GSE is an emerging therapy for its possible potential advantages to other therapies for treatment of acute viral respiratory infections. GSE appears to be safe, well tolerated, and in some trials to be beneficial in treating individuals that have severe asthma. Xylitol has been recommended as an adjunct therapy for influenza and other acute respiratory illnesses and has received FDA Fast-Track Designation status, which can speed the review and approval process for new drugs, as well as potential for FDA approval." - Anonymous Online Contributor

Unverified Answer

Have there been any new discoveries for treating covid-19?

"There are currently no available therapies for the treatment of COVID-19. At this time scientists are relying on anti-virals to reduce the risk of further spread of the disease." - Anonymous Online Contributor

Unverified Answer

Does covid-19 run in families?

"Given a genetic risk factor for both COVID-19 and CVD, we hypothesize that families with multiple cases of either would be more susceptible to a disease outbreak. It will be important to identify genetic pathways which may potentially be modulated by treatment strategies." - Anonymous Online Contributor

Unverified Answer

Who should consider clinical trials for covid-19?

"All clinicians should be aware of their potential role in the research-to-help-crisis pathway for covid-19. Clinicians have the opportunity to add to the research, but also to provide care, and such practice requires careful planning and ethical considerations. Further consideration should be given to the role of clinical trials for other infectious diseases." - Anonymous Online Contributor

Unverified Answer

Is gse and xylitol safe for people?

"For the study population, the study result suggest that in the absence of an effective oral treatment for COVID-19, use of xylitol may be a suitable option for preventing dental problems for dental clinic patients and for reducing the overall dental treatment costs." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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