Riboflavin drop every 10 minutes for Keratoconus

Phase-Based Progress Estimates
2
Effectiveness
3
Safety
Cornea and Laser Eye Institute, Hersh Vision Group, Teaneck, NJKeratoconus+1 MoreRiboflavin - Drug
Eligibility
Any Age
All Sexes
What conditions do you have?
Select

Study Summary

This trial sought to compare the efficacy of transepithelial CXL with conventional CXL in the treatment of progressive keratoconus.

Eligible Conditions
  • Keratoconus
  • Corneal Ectasia

Treatment Effectiveness

Study Objectives

1 Primary · 1 Secondary · Reporting Duration: 1 year

1 year
Mean keratometry
12 months
Maximum keratometry

Trial Safety

Trial Design

2 Treatment Groups

Riboflavin drop every 10 minutes
1 of 2
Riboflavin drop every 2 minutes
1 of 2

Active Control

160 Total Participants · 2 Treatment Groups

Primary Treatment: Riboflavin drop every 10 minutes · No Placebo Group · Phase 3

Riboflavin drop every 10 minutes
Drug
ActiveComparator Group · 1 Intervention: Riboflavin · Intervention Types: Drug
Riboflavin drop every 2 minutes
Drug
ActiveComparator Group · 1 Intervention: Riboflavin · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 1 year

Who is running the clinical trial?

Cornea and Laser Eye InstituteLead Sponsor
9 Previous Clinical Trials
953 Total Patients Enrolled
9 Trials studying Keratoconus
953 Patients Enrolled for Keratoconus
Peter S Hersh, MDStudy DirectorCornea and Laser Eye Institute - Hersh Vision Group
4 Previous Clinical Trials
353 Total Patients Enrolled
4 Trials studying Keratoconus
353 Patients Enrolled for Keratoconus
Steven A Greenstein, MDPrincipal InvestigatorCornea and Laser Eye Institute - Hersh Vision Group
2 Previous Clinical Trials
180 Total Patients Enrolled
2 Trials studying Keratoconus
180 Patients Enrolled for Keratoconus

Eligibility Criteria

Age Any Age · All Participants · 7 Total Inclusion Criteria

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Frequently Asked Questions

Did the FDA approve Riboflavin to be used every 10 minutes?

"This medication has been shown to be effective in prior clinical trials and has received multiple rounds of safety testing, so it received a score of 3." - Anonymous Online Contributor

Unverified Answer

What illness does Riboflavin drop every 10 minutes commonly help cure?

"Riboflavin, administered through drops every ten minutes, is often used to treat nutritional deficiencies. This vitamin can also ameliorate joint pain and be used as part of a general vitamin supplement routine." - Anonymous Online Contributor

Unverified Answer

Are there any other scientific investigations involving a similar Riboflavin dosing schedule?

"At the moment, there are 20 ongoing clinical trials for Riboflavin drop every 10 minutes. 11 of these studies are in Phase 3. Although most of the research for Riboflavin drop every 10 minutes is being conducted in San Francisco, there are a total of 47 research sites for this treatment." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.