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Corneal Collagen Crosslinking for Keratoconus
Study Summary
This trial sought to compare the efficacy of transepithelial CXL with conventional CXL in the treatment of progressive keratoconus.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
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- I am 12 years old or older.I have a history of corneal disease.I have been diagnosed with keratoconus or corneal ectasia after eye surgery.I have been diagnosed with keratoconus or corneal ectasia after eye surgery.My eye condition is related to keratoconus or corneal ectasia after surgery.I can attend all scheduled follow-up visits.I have noticeable scarring on my cornea where I received CXL treatment.I have removed my contact lenses for a week before the eye test.I have had a chemical injury or slow healing in my eye.I do not have any conditions that prevent me from keeping my gaze steady.My eyes have conditions that could lead to future problems.
- Group 1: Riboflavin drop every 2 minutes
- Group 2: Riboflavin drop every 10 minutes
- Pivotal Trial - The final step before approval, pivotal trials feature drugs that have already shown basic safety & efficacy.
- All Individual Drugs Already Approved - Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Did the FDA approve Riboflavin to be used every 10 minutes?
"This medication has been shown to be effective in prior clinical trials and has received multiple rounds of safety testing, so it received a score of 3."
What illness does Riboflavin drop every 10 minutes commonly help cure?
"Riboflavin, administered through drops every ten minutes, is often used to treat nutritional deficiencies. This vitamin can also ameliorate joint pain and be used as part of a general vitamin supplement routine."
Are there any other scientific investigations involving a similar Riboflavin dosing schedule?
"At the moment, there are 20 ongoing clinical trials for Riboflavin drop every 10 minutes. 11 of these studies are in Phase 3. Although most of the research for Riboflavin drop every 10 minutes is being conducted in San Francisco, there are a total of 47 research sites for this treatment."
Who else is applying?
What state do they live in?
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What portion of applicants met pre-screening criteria?
How many prior treatments have patients received?
Why did patients apply to this trial?
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