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Opioid Antagonist

Methylnaltrexone Bromide for Constipation (MOVE-IT Trial)

Phase 3
Waitlist Available
Led By Bradford A Whitmer, D.O.
Research Sponsored by St. John Health System, Michigan
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up nine months
Awards & highlights

MOVE-IT Trial Summary

The purpose of this study is to determine if there will be a significantly higher incidence of a bowel movement with methylnaltrexone vs. placebo within 4 hours +- 45 minutes with decreased need for rescue medications in the intensive care unit in patients with opioid-induced constipation. Patients will also be managed with an aggressive bowel management protocol.

Eligible Conditions
  • Constipation

MOVE-IT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~nine months
This trial's timeline: 3 weeks for screening, Varies for treatment, and nine months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
A significantly higher incidence of a rescue free laxation with methylnaltrexone within 4 hours +- 45 minutes.
Secondary outcome measures
Decreased need for rescue medications to have a bowel movement in the treatment arm vs placebo.

MOVE-IT Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: Methylnaltrexone BromideActive Control1 Intervention
Group II: PlaceboPlacebo Group1 Intervention

Find a Location

Who is running the clinical trial?

St. John Health System, MichiganLead Sponsor
5 Previous Clinical Trials
1,879 Total Patients Enrolled
Bradford A Whitmer, D.O.Principal InvestigatorProvidence Hospital and Medical Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit
2009. "Methylnaltrexone for Treatment of Opiate-Induced Constipation in the Intensive Care Unit". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT01050595.
All > Constipation
~5 spots leftby May 2025
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