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Nonsteroidal Anti-inflammatory Drug

325 mg Aspirin for Colorectal Cancer

Phase 2
Waitlist Available
Led By Jason Zell, MD
Research Sponsored by University of California, Irvine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Subjects must be 18-80 years of age with a history of surgically removed colon or rectal cancer, and have received treatment for their disease using drugs (adjuvant chemotherapy)
Subjects must have colon or rectal cancer with stage I, II, or III disease
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

Study Summary

This trial is testing aspirin and a diet restricted in the amino acid arginine to see if it can lower certain biomarkers associated with colorectal cancer in patients who have already been treated for the disease.

Eligible Conditions
  • Colorectal Cancer

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Rectal Tissue Putrescine Reduction
Secondary outcome measures
Safety/Toxicity

Trial Design

1Treatment groups
Experimental Treatment
Group I: 325 mg AspirinExperimental Treatment1 Intervention
325 mg aspirin po qd with arginine-restricted diet
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acetylsalicylic acid
FDA approved

Find a Location

Who is running the clinical trial?

University of California, IrvineLead Sponsor
541 Previous Clinical Trials
1,921,866 Total Patients Enrolled
Jason Zell, MDPrincipal InvestigatorChao Family Comprehensive Cancer Center

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Trial of Aspirin and Arginine Restriction in Colorectal Cancer
Jason Zell 2008. "Trial of Aspirin and Arginine Restriction in Colorectal Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00578721.
~1 spots leftby Apr 2025
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