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Local consolidative therapy for Colorectal Cancer

Phase 2
Waitlist Available
Led By Joshua Meyer, MD
Research Sponsored by Fox Chase Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 6 months
Awards & highlights

Study Summary

This trial is studying how well a combination of local consolidative therapy with systemic therapy works in treating patients with colorectal cancer that has spread to a limited number of sites and has progressed after initial treatment.

Eligible Conditions
  • Colorectal Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~6 months
This trial's timeline: 3 weeks for screening, Varies for treatment, and 6 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression free survival
Secondary outcome measures
Overall suvival (OS)
Patient reported outcomes (PROs)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Local consolidative therapy (LCT) + systemic therapyExperimental Treatment1 Intervention
Local Consolidative Therapy (LCT) will be defined as surgical resection or stereotactic body radiotherapy (SBRT) or a combination of both strategies
Group II: Systemic therapy aloneActive Control1 Intervention
Appropriate second-line systemic therapy, as defined in the NCCN guidelines will be used during study treatment (https://www.nccn.org/professionals/physician_gls/pdf/colon.pdf). The choice of specific regimen will be left to the discretion of the treating oncologist but cannot include other experimental or investigational treatment. Sample appropriate systemic therapies include FOLFOX or FOLFIRI with a biologic agent such as an anti-angiogenic antibody or anti-EGFR antibody.

Find a Location

Who is running the clinical trial?

Fox Chase Cancer CenterLead Sponsor
227 Previous Clinical Trials
37,509 Total Patients Enrolled
Varian Medical SystemsIndustry Sponsor
58 Previous Clinical Trials
3,739 Total Patients Enrolled
Joshua Meyer, MDPrincipal InvestigatorFox Chase Cancer Center
6 Previous Clinical Trials
223 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Local Consolidative Therapy in Colorectal Cancer
2021. "Local Consolidative Therapy in Colorectal Cancer". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT05062720.
~0 spots leftby Apr 2025
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