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Janus kinase (JAK) inhibitor

Tofacitinib for Ulcerative Colitis (TRIUMPH Trial)

Phase 2
Waitlist Available
Led By Neeraj Narula, MD
Research Sponsored by McMaster University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 7 days
Awards & highlights
All Individual Drugs Already Approved
No Placebo-Only Group
Approved for 10 Other Conditions

Summary

This trial will study whether tofacitinib can help treat ulcerative colitis in hospitalized patients.

Eligible Conditions
  • Ulcerative Colitis Acute

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~7 days
This trial's timeline: 3 weeks for screening, Varies for treatment, and 7 days for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Clinical response at day 7

Awards & Highlights

All Individual Drugs Already Approved
Therapies where all constituent drugs have already been approved are likely to have better-understood side effect profiles.
No Placebo-Only Group
All patients enrolled in this study will receive some form of active treatment.
Approved for 10 Other Conditions
This treatment demonstrated efficacy for 10 other conditions.

Trial Design

1Treatment groups
Experimental Treatment
Group I: Treatment armExperimental Treatment1 Intervention
Tofacitinib 10mg PO BID

Find a Location

Who is running the clinical trial?

McMaster UniversityLead Sponsor
912 Previous Clinical Trials
2,614,037 Total Patients Enrolled
5 Trials studying Ulcerative Colitis
885 Patients Enrolled for Ulcerative Colitis
University of ManitobaOTHER
616 Previous Clinical Trials
206,687 Total Patients Enrolled
4 Trials studying Ulcerative Colitis
2,206 Patients Enrolled for Ulcerative Colitis
University of British ColumbiaOTHER
1,457 Previous Clinical Trials
2,484,551 Total Patients Enrolled
8 Trials studying Ulcerative Colitis
2,032 Patients Enrolled for Ulcerative Colitis
~6 spots leftby Oct 2025
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