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Cholinesterase Inhibitor

Donepezil for Cognitive Impairment (Remember Trial)

Phase 3
Waitlist Available
Led By Stephen R Rapp, PhD
Research Sponsored by Wake Forest University Health Sciences
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, weeks 12, 24, 36
Awards & highlights

Remember Trial Summary

This study is evaluating whether a drug commonly used to treat Alzheimer's disease may help improve memory in breast cancer patients.

Eligible Conditions
  • Cognitive Impairment
  • Memory Loss

Remember Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, weeks 12, 24, 36
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, weeks 12, 24, 36 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Hopkins Verbal Learning Test-Revised (HVLT-R) - Total
Secondary outcome measures
Controlled Oral Word Association Test (COWA) Results
Digit Span Test-Backwards (DST-B)
Digit Symbol Coding Results
+3 more

Remember Trial Design

2Treatment groups
Active Control
Placebo Group
Group I: DonepezilActive Control1 Intervention
Participants will be asked to take one 5 mg tablet of donepezil daily for 6 weeks followed by two 5 mg tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.
Group II: PlaceboPlacebo Group1 Intervention
Participants will be asked to take one tablet of matching placebo daily for 6 weeks followed by two tablets daily for 18 weeks. After 24 weeks, participants will begin a 12 week wash-out period.

Find a Location

Who is running the clinical trial?

Wake Forest University Health SciencesLead Sponsor
1,243 Previous Clinical Trials
1,004,450 Total Patients Enrolled
National Cancer Institute (NCI)NIH
13,667 Previous Clinical Trials
40,925,890 Total Patients Enrolled
Stephen R Rapp, PhDPrincipal InvestigatorWake Forest University Health Sciences
2 Previous Clinical Trials
3,624 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil
2017. "Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02822573.
~35 spots leftby Apr 2025
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