Structured exercise for Cognitive Decline

2
Effectiveness
3
Safety
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA, Boston, MA
Cognitive Decline+1 More
Structured exercise - Behavioral
Eligibility
18+
All Sexes
Eligible conditions
Cognitive Decline

Study Summary

This study is evaluating whether a home-based exercise intervention can improve episodic memory in individuals with mild cognitive impairment.

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Eligible Conditions

  • Cognitive Decline
  • Cognitive Dysfunction
  • Mild Cognitive Impairment (MCI)

Treatment Effectiveness

Effectiveness Estimate

2 of 3
This is better than 85% of similar trials

Study Objectives

This trial is evaluating whether Structured exercise will improve 1 primary outcome and 1 secondary outcome in patients with Cognitive Decline. Measurement will happen over the course of 6 months.

6 months
Rey-Osterrieth Complex Figure Test
Wechsler Logical Memory Task

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

2 Treatment Groups

Control group
Exercise group

This trial requires 60 total participants across 2 different treatment groups

This trial involves 2 different treatments. Structured Exercise is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.

Exercise group
Behavioral
Structured exercise
Control group
Behavioral
Health education
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Structured exercise
2013
N/A
~170

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: 6 months
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly 6 months for reporting.

Closest Location

VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA - Boston, MA

Eligibility Criteria

This trial is for patients born any sex aged 18 and older. There are 2 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
Amnestic MCI
Ability to use a telephone without assistance

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many people get cognitive decline a year in the United States?

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Although many older adults have some complaints about their eyesight and/or hearing, only 2% are affected by both, compared with 1% for both and vision or hearing complaints alone.

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What is cognitive decline?

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Cognitive deficits in brain injury patients are associated with deficits in some specific cognitive functions; more rigorous evaluation of the contribution of other factors to cognitive deficits in brain injured patients is needed to maximize their potential therapeutic benefits.

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What are common treatments for cognitive decline?

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Cognitive decline is common in older adults. There is only one FDA-approved treatment for cognitive decline: [acetylcholinesterase (AChE) inhibitor or mamestrol]. Older adults are also being prescribed a wider variety of over-the-counter treatments and supplements, including multiple AChE inhibitor products, and even non-acetyl cholinesterase (non-AChE) inhibitors, that could improve, but not cure cognitive functioning.

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What are the signs of cognitive decline?

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The prevalence of at least one cognitive impairment is a significant predictor of functional decline in the community as well as in-home assessments of functional ability. Older persons with elevated risk factors for cognitive decline, such as a history of stroke, have an increased hazard of functional decline. The clinical presentation of cognition should thus be evaluated routinely and the appropriate preventive and management strategies evaluated and addressed.

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Can cognitive decline be cured?

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In terms of treatment success, a significant proportion of persons, regardless of diagnosis, showed modest improvement by 6 and 12 months respectively. However, there were no associations between the magnitude of neuropsychological test improvements and the magnitude of change in self-reported function. Findings from a recent study suggest a dissociation between clinically-observed, quantifiable improvements in neuropsychological functioning and clinically-observed improvements in perceived functioning.

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What causes cognitive decline?

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Although studies on the effects of a number of variables from early disease stages (e.g., younger patient age, less severe impairment, better function overall) were not fully informative, this study provides preliminary evidence of the potential causal impact of a variety of factors, beyond the traditional ones of age and disease severity, on cognitive decline among people with multiple myeloma.

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What are the common side effects of structured exercise?

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The present meta-review revealed that exercise had a range of common and unpleasant side effects, which can limit the potential use of exercise interventions in the prevention or treatment of cognitive decline.

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Has structured exercise proven to be more effective than a placebo?

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There may be a potential benefit to standardized aerobic exercise in improving cognitive function and slowing cognitive decline, however more studies are needed to fully support this conclusion.

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Does structured exercise improve quality of life for those with cognitive decline?

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Structured exercise may improve quality of life for those with cognitive decline. Recent findings of this observational study suggest that exercise may be a promising avenue to promote health outcomes in this population.

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Who should consider clinical trials for cognitive decline?

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Physicians need to consider the age (over 65), patient preference, motivation and baseline cognition as possible confounders for dementia risk. Inclusion and exclusion criteria may need to be adjusted in the future to prevent enrollment of patients not interested in clinical trials.

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Is structured exercise typically used in combination with any other treatments?

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The majority of clinicians will support some type of structured exercise as a component of their multimodal treatment for seniors with dementia, and that a large majority recommend that it be implemented at a gradual pace.

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Have there been other clinical trials involving structured exercise?

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No clinical trials that use the structured exercise approach studied other than one trial in the elderly. Results from a recent paper, participants were older than 55 years and all were [healthy as determined by not having a history of cardiovascular disease, diabetes, or cancer]. Further research on structured exercise has a great need and structured exercise approaches might one day become standard therapy for healthy adults.

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