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Local Anesthetic

Lidocaine Infusion for Chronic Pain in Children

Phase 3
Waitlist Available
Led By Lisa Isaac, MD
Research Sponsored by The Hospital for Sick Children
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 65 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up change from baseline pain score (7 days prior to infusion) at 14 days after completion of infusion
Awards & highlights

Summary

This trial tests if lidocaine given through an IV can reduce long-term pain in children who haven't been helped by other treatments. Researchers will measure pain levels and daily activities to see if it works and is safe. Intravenous lidocaine has been studied for its pain-relieving effects in various conditions, including chronic pain and post-operative pain.

Eligible Conditions
  • Chronic Pain

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week prior to the infusion and at two and four weeks following the infusion.
This trial's timeline: 3 weeks for screening, Varies for treatment, and week prior to the infusion and at two and four weeks following the infusion. for reporting.

Treatment Details

Study Objectives

Study objectives can provide a clearer picture of what you can expect from a treatment.
Primary study objectives
Pain Score
Secondary study objectives
Adverse Events
Analgesic Requirement
Other study objectives
Pain Interference
School Attendance
Sleep

Side effects data

From 2014 Phase 4 trial • 40 Patients • NCT01602692
40%
Nausea
10%
Vomiting
100%
80%
60%
40%
20%
0%
Study treatment Arm
Tumescent Solution With Dilute Epinephrine
Tumescent Solution With Dilute Lidocaine and Epinephrine

Trial Design

1Treatment groups
Experimental Treatment
Group I: Lidocaine InfusionExperimental Treatment1 Intervention
All participants will receive intravenous lidocaine infusion of 42 mcg/kg/minute over 2 hours, for a total of 5 mg/kg. No bolus dose will be given.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Lidocaine Infusion
2010
Completed Phase 4
~410

Find a Location

Who is running the clinical trial?

The Hospital for Sick ChildrenLead Sponsor
704 Previous Clinical Trials
6,956,858 Total Patients Enrolled
8 Trials studying Chronic Pain
1,028 Patients Enrolled for Chronic Pain
Lisa Isaac, MDPrincipal InvestigatorThe Hospital for Sick Children

Media Library

Lidocaine (Local Anesthetic) Clinical Trial Eligibility Overview. Trial Name: NCT02983682 — Phase 3
Chronic Pain Research Study Groups: Lidocaine Infusion
Chronic Pain Clinical Trial 2023: Lidocaine Highlights & Side Effects. Trial Name: NCT02983682 — Phase 3
Lidocaine (Local Anesthetic) 2023 Treatment Timeline for Medical Study. Trial Name: NCT02983682 — Phase 3
~2 spots leftby Oct 2025