This trial is evaluating whether Ziltivekimab will improve 4 primary outcomes and 43 secondary outcomes in patients with Inflammation. Measurement will happen over the course of From randomisation (month 0) to end-of-study (up to 48 months)..
This trial requires 6200 total participants across 2 different treatment groups
This trial involves 2 different treatments. Ziltivekimab is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
"If patients take an effective medication for as long as possible, their risk of cardiovascular diseases can be reduced. Therefore, it is important to initiate a drug treatment as early as possible, avoiding complications and allowing patients to maintain or even increase their activities." - Anonymous Online Contributor
"Cardiovascular diseases (CVD) consist of a group of disorders and diseases that share a number of causal factors and risk factors. Although CVD is a significant cause of morbidity and mortality, its primary prevention is not feasible with current medical technology in the 21st century and current medical and socioeconomic factors. CVD is also costly to the society which is due to increased healthcare expenditure, disability, and fatalities. CVD mortality in South Asia is among the highest. Epidemiology, prevention, and research studies as well as clinical and public health practices are important to improve survival from CVD." - Anonymous Online Contributor
"Based on the number of cardiovascular diseases (as represented by hospitalizations) documented in the U.S. database (n = 5,478,638), the average CVD patient experiences 1.8 hospitalizations per year. This number is likely substantially underestimated. The fact that there are 3.5 million hospitalizations for CVDs a year underscores the importance of timely recognition and management of CVDs for the prevention of its morbidity, mortality and cost to the patient." - Anonymous Online Contributor
"Many of those with signs of cardiovascular disease use them as a first aid, but the signs are not generally recognised as such, which could lead to delays in seeking appropriate care. Those who have unexplained recurrent respiratory infection are more likely to be under screened by medical practitioners. The majority of patients with cardiovascular risk factors are under-invited for specialist consultations for cardiac health. We suggest screening for cardiovascular risk factors, including those with chest pain, those aged >50 years or those living alone. It may also be useful for health professionals to examine signs of cardiovascular disease in people with unexplained fatigue." - Anonymous Online Contributor
"The most common treatments for some typical cardiovascular diseases and indications of its usage include: Beta blockers, calcium channel blocker, ACE(I/E inhibitors), thiazide, statins, aspirin, angiotensin II receptor blocker, and anticoagulant." - Anonymous Online Contributor
"Coronary artery disease (CAD) begins with exposure to risk factors such as smoking, diabetes mellitus and hypertension. The risk for progression to symptomatic disease increases with the number of risk factors present. The risk of serious cardiovascular diseases increases 10-fold in patients with three or more risk factors. For most of these patients atherosclerosis is the predominant underlying cause of CAD. Thus, the disease process is highly amenable to medical treatment designed to reduce the effects of coronary atherosclerosis. Therefore, all patients with CAD need regular medical surveillance to detect progress of the disease, and to initiate preventive measures." - Anonymous Online Contributor
"The authors believe that patients' general interest and self-perception are not reliable enough to make people decide on whether or not to take part in a clinical trial. Considering only the patients' perspective is likely to miss those patients who would probably benefit and is likely to lead to suboptimal treatment." - Anonymous Online Contributor
"The majority of CVDs are highly preventable by lifestyle changes, health literacy, and access to the health care system, while the primary causes are high levels of blood pressure, unhealthy diet and tobacco use. The United Kingdom's Health and Social Care Reform Policy has led to changes in lifestyle habits." - Anonymous Online Contributor
"The preliminary results of the present study may serve as a useful guide to design and carry out further clinical study on ziltivekimab after completion of the Phase III MONITOR trial in March 2014." - Anonymous Online Contributor
"Data from a recent study of the present review give an overview of the most recent advances of medical treatments for cardiovascular diseases. We show how innovative and high-risk therapies have been introduced in the past 20 years, and we indicate the potential of future advances." - Anonymous Online Contributor
"The CVD-related gene variants identified in the present population are mainly those that are related to coronary and valvular heart disease, in particular of ascending aortic aneurysms, and so CVRF mutations are associated with the development of cardiovascular diseases." - Anonymous Online Contributor
"There have been many improvements for treating coronary artery disease but we are still far from a complete understanding. Nevertheless, there were many advances in the use of statins and fibrates to treat heart disease and also for use in cancer treatment." - Anonymous Online Contributor