430 Participants Needed

Digital Cognitive Behavioral Therapy for Insomnia

RJ
Overseen ByRJ Johnson, MA
Age: 18+
Sex: Any
Trial Phase: Phase 4
Sponsor: National Jewish Health
Must be taking: Hypnotics
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Prior Safety DataThis treatment has passed at least one previous human trial

Trial Summary

What is the purpose of this trial?

Many individuals with insomnia seek treatment in primary care settings, where they often receive prescription hypnotic medications as their first and sometimes only treatment. However, extended use of these medications can lead to reliance and increased health risks, such as falls and cognitive impairments. While evidence-based approaches like physician-supervised medication tapering exist, they're not widely available in primary care. Most primary care providers are willing to explore non-drug treatments like cognitive behavioral therapy for insomnia (CBTI), but accessing such treatments can be challenging outside of specialized sleep centers. This gap between research and practice underscores the need for cost-effective interventions to manage insomnia and help patients reduce their reliance on hypnotics in primary care. In response to this need, the project aims to conduct a large randomized trial comparing a combined digital CBT (dCBTI) and medication tapering intervention with medication tapering alone. We'll recruit 430 patients reliant on hypnotics from 8-10 primary care clinics affiliated with the University of Colorado Medical School. The main goal is to assess the effectiveness of dCBTI+SMT compared to SMT alone in reducing hypnotic use and improving insomnia symptoms. Additionally, we'll evaluate factors affecting the adoption and implementation of these interventions at the patient, provider, and system levels. This information will inform future implementation strategies to disseminate effective treatments in primary care. Furthermore, we'll gather data to identify which patients benefit most from dCBTI+SMT. Overall, this study will provide valuable insights into the feasibility, clinical utility, and acceptability of these interventions in managing insomnia and reducing reliance on hypnotic medications in primary care. Ultimately, this project represents a crucial first step toward making accessible and cost-effective strategies available to improve the quality of life for millions of chronic users of sleep aids.

Will I have to stop taking my current medications?

The trial focuses on reducing or eliminating the use of hypnotic medications for insomnia, so you may need to taper off these medications as part of the study. However, the protocol does not specify if you must stop other medications, but it does exclude those using certain medications for other conditions.

What data supports the effectiveness of the treatment Digital Cognitive Behavioral Therapy for Insomnia?

Research shows that digital cognitive behavioral therapy for insomnia (dCBT-I) is effective in improving sleep quality and reducing insomnia severity. It has been found to be as effective as traditional therapy and helps improve overall quality of life by addressing the daytime consequences of poor sleep.12345

Is digital cognitive behavioral therapy for insomnia safe for humans?

Digital cognitive behavioral therapy for insomnia has been studied in various trials and is generally considered safe for humans, with improvements in well-being and quality of life reported.12467

How is digital cognitive behavioral therapy for insomnia different from other treatments?

Digital cognitive behavioral therapy for insomnia (dCBT-I) is unique because it is delivered through digital platforms, making it more accessible and scalable compared to traditional in-person therapy. It focuses on changing thoughts and behaviors related to sleep, and unlike medication, it addresses the root causes of insomnia without the risk of side effects.12468

Eligibility Criteria

This trial is for adults with insomnia who've been using sleep meds (benzodiazepine or non-benzodiazepine) regularly for over 6 months and want to cut down. They must meet the DSM-5 criteria for insomnia disorder and be willing to consent to participate.

Inclusion Criteria

I am willing to sign a consent form to participate.
I want to reduce or stop using sleep medications.
I have used sleep medication almost every night for more than 6 months.
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either digital cognitive behavioral therapy combined with structured medication tapering or structured medication tapering alone

22 weeks
Regular visits as per treatment protocol

Follow-up

Participants are monitored for insomnia remission and hypnotic discontinuation rates

27 weeks
Post-treatment assessments at weeks 22 and 49

Treatment Details

Interventions

  • Digital Cognitive Behavioral Therapy
  • Structured Medication Tapering
Trial Overview The study tests if digital Cognitive Behavioral Therapy combined with a structured plan to gradually reduce sleep medication is more effective than reducing medication alone in primary care patients dependent on hypnotics.
Participant Groups
2Treatment groups
Experimental Treatment
Group I: Structured medication tapering aloneExperimental Treatment1 Intervention
Structured medication tapering delivered alone with general sleep hygiene information.
Group II: Digital cognitive behavioral therapy combined with structured medication taperingExperimental Treatment2 Interventions
dCBTI delivered in tandem with SMT during intervention phase.

Find a Clinic Near You

Who Is Running the Clinical Trial?

National Jewish Health

Lead Sponsor

Trials
145
Recruited
318,000+

Findings from Research

Digital cognitive behavior therapy for insomnia (dCBT-I) significantly improves sleep quality in patients with insomnia, particularly in those with anxiety disorders, as shown in a study of 6,002 patients over a 12-week period.
Patients receiving dCBT-I monotherapy and those with combined therapy showed notable improvements in sleep quality, with the most significant changes observed in the anxiety group, indicating that dCBT-I is a practical and effective treatment option.
Digital cognitive behavior therapy for insomnia improving sleep quality: a real-world study.Liang, S., Mao, H., Yang, J., et al.[2022]
Digital cognitive behavioral therapy (dCBT) significantly improves functional health, psychological well-being, and sleep-related quality of life in individuals with insomnia, based on a study of 1711 participants over 24 weeks.
The reduction in insomnia symptoms was a key factor mediating these improvements, highlighting that dCBT effectively addresses both daytime and nighttime issues related to poor sleep.
Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial.Espie, CA., Emsley, R., Kyle, SD., et al.[2023]
Digital cognitive behavioral therapy for chronic insomnia (D-CBT-I) is effective, with 46.4% of 414 participants achieving remission after a 6-week treatment, making it a strong first-line option for chronic insomnia.
Factors such as longer early morning awakening times and higher baseline insomnia severity negatively impacted treatment outcomes, suggesting that patients with milder insomnia and more severe depressive symptoms may benefit more from D-CBT-I.
Factors influencing the effectiveness of digital cognitive behavioural therapy for chronic insomnia in clinical practice.Shi, Y., Ren, R., Zhang, Y., et al.[2023]

References

Digital cognitive behavior therapy for insomnia improving sleep quality: a real-world study. [2022]
Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial. [2023]
Factors influencing the effectiveness of digital cognitive behavioural therapy for chronic insomnia in clinical practice. [2023]
Digital Cognitive Behavioral Therapy for Insomnia Using a Smartphone Application in China: A Pilot Randomized Clinical Trial. [2023]
A pilot evaluation of an online cognitive behavioral therapy for insomnia disorder - targeted screening and interactive Web design lead to improved sleep in a community population. [2021]
Comparative Effectiveness of Digital Cognitive Behavioral Therapy vs Medication Therapy Among Patients With Insomnia. [2023]
Long-term benefits of digital cognitive behavioural therapy for insomnia: Follow-up report from a randomized clinical trial. [2021]
The effect of sleep-wake intraindividual variability in digital cognitive behavioral therapy for insomnia: a mediation analysis of a large-scale RCT. [2021]
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