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Alkylating agent

Paclitaxel, carboplatin and metformin for Ovarian Cancer

Phase 2
Waitlist Available
Led By Lisa N Abaid, M.D., M.P.H.
Research Sponsored by Gynecologic Oncology Associates
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

Study Summary

Initially, the prospect of metformin as a neoplastic treatment was considered for malignancies of the prostate, colon and pancreas. However, only select clinical studies involving the use of metformin in the treatment of ovarian cancer have documented improved survival rates. Since no first line regimen has demonstrated compelling superiority in the management of advanced stage ovarian carcinoma, the combination of paclitaxel, carboplatin, and metformin is of particular interest given the triplet's prospect for achieving increased synergy without compromising patient tolerability.

Eligible Conditions
  • Ovarian Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Progression free survival
Secondary outcome measures
Metabolic biomarker evaluation

Trial Design

1Treatment groups
Experimental Treatment
Group I: Paclitaxel, carboplatin and metforminExperimental Treatment3 Interventions
Drug: Metformin (850 mg) Drug: Carboplatin (AUC 5 or 6) Drug: Paclitaxel (80 mg/m2) The regimen will be administered as a dose dense schedule.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Metformin
FDA approved
Paclitaxel
FDA approved
Carboplatin
FDA approved

Find a Location

Who is running the clinical trial?

University of North Carolina, Chapel HillOTHER
1,508 Previous Clinical Trials
4,190,952 Total Patients Enrolled
Gynecologic Oncology AssociatesLead Sponsor
3 Previous Clinical Trials
58 Total Patients Enrolled
1 Trials studying Ovarian Cancer
20 Patients Enrolled for Ovarian Cancer
Lisa N Abaid, M.D., M.P.H.Principal InvestigatorGynecologic Oncology Associates

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma
2014. "Study of Paclitaxel, Carboplatin and Oral Metformin in the Treatment of Advanced Stage Ovarian Carcinoma". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02437812.
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~3 spots leftby Apr 2025
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