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NovoTTF-100L(O) for Ovarian Cancer

Phase 3

Waitlist Available

Led By Ignace Vergote, MD

Research Sponsored by NovoCure Ltd.

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up 4 years

Awards & highlights

Study Summary

This trial is testing a new cancer treatment that uses electric fields to kill ovarian cancer cells.

Eligible Conditions

Ovarian Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 4 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~4 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and 4 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Overall survival

Secondary outcome measures

Next progression-free survival

Objective response rate

Progression-free survival

+4 more

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: NovoTTF-100L(O)Experimental Treatment2 Interventions

Patients receive TTFields using the NovoTTF-100L(O) System together with weekly Paclitaxel

Group II: Best Standard of CareActive Control1 Intervention

Patients receive best standard of care with weekly Paclitaxel

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

NovoTTF-100L(O)

2019

Completed Phase 3

~540

Paclitaxel

2011

Completed Phase 4

~5380

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

NovoCure Ltd.Lead Sponsor

57 Previous Clinical Trials

4,182 Total Patients Enrolled

Ignace Vergote, MDPrincipal InvestigatorUniversity Hospitals Leuven, Leuven Cancer Institute

1 Previous Clinical Trials

116 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How is NovoTTF-100L(O) most commonly used?

"NovoTTF-100L(O) is a versatile intervention that can be used to treat neoplasm metastasis, kaposi sarcoma, and fallopian tubes cancer, among other conditions."

Answered by AI

Are there a lot of locations running this research project in different states?

"There are 63 clinical trial sites for this study, for example Women's Cancer Center of Nevada in Las Vegas, Washington University School of Medicine in St. Louis in Saint Louis, and Abington Hospital- Asplundh Cancer Pavilion in Willow Grove."

Answered by AI

Are there any volunteers required for this clinical trial at the moment?

"Unfortunately, this particular study is not searching for patients to enroll at this time. Based on the dates that are provided, the last time that this study was active was on April 19th, 2022. However, there are 698 other trials that you could look into that are currently searching for patients with ovary cancer and 874 studies for NovoTTF-100L(0) that are actively recruiting patients."

Answered by AI

Does NovoTTF-100L(O) have any potential harmful side effects?

"There is some clinical data to support the efficacy of NovoTTF-100L(O), and as this is a Phase 3 trial, there are also multiple rounds of data to support its safety; thus, we have given it a score of 3."

Answered by AI

Are there precedent cases for using NovoTTF-100L(O) in treatments?

"The first study into NovoTTF-100L(O)'s efficacy was conducted in 1997 at City of Hope Comprehensive Cancer Center. There have been 1140 completed studies thus far. There are 874 live trials at the moment, with a large number of them based in Las Vegas, Nevada."

Answered by AI

Who else is applying?

What state do they live in?

Kentucky

Texas

How old are they?

18 - 65

What portion of applicants met pre-screening criteria?

Met criteria

Did not meet criteria

What site did they apply to?

Norton Cancer Institute

Texas Oncology-Tyler

How many prior treatments have patients received?

Why did patients apply to this trial?

I don't know why I can't have kids, maybe I can learn more about myself doing this an help my living situation in the process.

PatientReceived 1 prior treatment

1st chemo gave me remission of 8 years. 2nd chemo CA-125 went down every month of treatment, and also went down first month of no treatment, then steadily started going back up. Same chemo was restarted, and CA-125 is going down again, but I have no faith in any extended remission. I just had my 4th chemo of this round last week.

PatientReceived 2+ prior treatments