This trial is testing a new cancer drug to see if it's effective and safe. It includes 7 groups of patients with different types of lung cancer, and will last for 603 patients.
- Non-Small Cell Lung Cancer
1 Primary · 2 Secondary · Reporting Duration: 24 months
Side Effects for
Awards & Highlights
1 Treatment Group
1 of 1
603 Total Participants · 1 Treatment Group
Primary Treatment: Poziotinib · No Placebo Group · Phase 2
Who is running the clinical trial?
Age 18+ · All Participants · 1 Total Inclusion CriteriaMark “Yes” if the following statements are true for you:
- Le, Xiuning, Robin Cornelissen, Marina Garassino, Jeffrey M. Clarke, Nishan Tchekmedyian, Jonathan W. Goldman, Szu-Yun Leu, et al.. 2022. “Poziotinib in Non–small-cell Lung Cancer Harboring her2 Exon 20 Insertion Mutations After Prior Therapies: ZENITH20-2 Trial”. Journal of Clinical Oncology. American Society of Clinical Oncology (ASCO). doi:10.1200/jco.21.01323.
- 2017. "Phase 2 Study of Poziotinib in Patients With NSCLC Having EGFR or HER2 Exon 20 Insertion Mutation". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT03318939.
Frequently Asked Questions
Is this the pioneering trial of its kind?
"Since its first clinical trial in 2017, sponsored by Spectrum Pharmaceuticals, Inc. and involving 80 participants, Poziotinib has been thoroughly studied with 5 current trials running across 49 cities and 9 nations. Subsequent to the initial study it was granted Phase 2 drug approval." - Anonymous Online Contributor
What is the aggregate size of the cohort engaged in this medical experiment?
"In order to conduct the study, 603 suitable participants must be enrolled. The sponsor, Spectrum Pharmaceuticals Inc., will undertake recruitment at multiple sites such as North Shore Hematology Oncology Associates DBA New York Cancer and Blood Specialists in Bronx, New York and Virginia Cancer Specialists PC in Fairfax, Virginia." - Anonymous Online Contributor
How many sites are currently carrying out this research?
"North Shore Hematology Oncology Associates DBA New York Cancer and Blood Specialists in Bronx, NY, Virginia Cancer Specialists PC in Fairfax, VA and Kaiser Permanente Medical Center in Vallejo, CA are among the 40 different medical sites running this trial." - Anonymous Online Contributor
Are there any vacancies in this medical experiment for participants?
"Indeed, clinicaltrials.gov asserts that this medical initiative is actively seeking participants after first being posted on October 13th 2017 and most recently edited in February 24th 2022. 603 persons are required across 39 different locations to take part in the study." - Anonymous Online Contributor
Has Poziotinib been sanctioned by the U.S. Food and Drug Administration?
"Poziotinib's safety, which has been partially verified by clinical data from a Phase 2 trial, is assigned an approximate score of 2." - Anonymous Online Contributor
Are any other tests being conducted to assess the efficacy of Poziotinib?
"Poziotinib was initially studied in 2017 at the M D Anderson Cancer Center, and 11 studies have been successfully concluded since then. In addition to these completed trials, there are currently 5 active clinical trials with a significant number of them being conducted near Bronx, New York." - Anonymous Online Contributor