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Drug Combinations for Kidney Cancer
Study Summary
This trial is testing six different combinations of two drugs to see which is most effective in treating metastatic kidney cancer.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowTimeline
Treatment Details
Study Objectives
Outcome measures can provide a clearer picture of what you can expect from a treatment.Trial Design
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Who is running the clinical trial?
Media Library
- Your diabetes is not well managed, as shown by high fasting blood sugar levels.I am not allergic to bevacizumab, pazopanib, or everolimus.I am not planning to take any experimental drugs but can take bisphosphonates while in this study.I do not have multiple brain tumors or cancer in the lining of my brain, but may have one controlled brain tumor.I can swallow pills.I have a serious wound or fracture that is not healing.I do not have severe liver disease or cirrhosis.I am 18 years old or older.I haven't had targeted or chemotherapy for my kidney cancer, but may have had immunotherapy.I am not pregnant or breastfeeding.I haven't had major surgery or a serious injury in the last 28 days and don't expect to need major surgery during the study.I don't have a history of bleeding disorders but may be on blood thinners.I am not taking rifampin, St. John's wort, or certain seizure medications.I haven't had any major abdominal issues like fistula, perforation, or abscess in the last 6 months.My lung function is severely impaired, with low oxygen levels or less than half the normal lung capacity.You have a disease that can be measured or observed.Your blood counts and organ function need to be within certain levels to be eligible for the study. This includes having a certain level of white blood cells and platelets, and your liver and kidney functions need to be within specific ranges.I am a woman who can have children and have a recent negative pregnancy test.I have not had a stroke or mini-stroke in the last 6 months.I do not have serious heart problems.I have symptoms of poor blood flow in my limbs.I am not on long-term steroids or immune-suppressing drugs, except for low-dose or topical use.I do not have high levels of protein in my urine.My blood pressure is controlled and I have never had a hypertensive crisis.I have coughed up a significant amount of blood recently.I have a serious blood vessel condition like an aortic aneurysm.My kidney cancer has spread and shows clear cell features.I had surgery or a procedure to remove or treat my kidney tumor.I am fully active or can carry out light work.I am not HIV-positive or on anti-retroviral therapy.I am not receiving treatment for any cancer other than kidney cancer.I do not have any infections that aren't responding to treatment.I haven't had any live vaccines recently and will avoid close contact with anyone who has.I am eligible regardless of my gender, race, or ethnicity.
- Group 1: Group 6
- Group 2: Group 1
- Group 3: Group 5
- Group 4: Group 2
- Group 5: Group 4
- Group 6: Group 3
- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
Are there any available spots left for volunteers in this experiment?
"This study is not currently accepting patients. The original posting date was January 19th, 2011 and the most recent update was on October 11th, 2022. If you are looking for other studies, there are presently 2724 studies actively recruiting patients with kidney neoplasms and 489 trials for Everolimus actively looking for patients."
What are some of the common conditions that Everolimus has been known to improve?
"Everolimus has demonstrated efficacy in the treatment of malignant neoplasms and conditions such as recurrent platinum sensitive primary peritoneal cancer, rejection; transplant, kidney, and waldenstrom macroglobulinemia."
What is the clinical evidence for Everolimus' efficacy?
"There are 489 ongoing clinical trials for Everolimus, with 121 of them being Phase 3 trials. Many of these studies are based in Taibei, Taiwan; however, there are 24499 total locations running these clinical trials."
Is Everolimus a safe medication for human beings?
"While there is some data indicating that Everolimus is safe, it only received a score of 2 because this is a Phase 2 trial and thus there is no evidence for efficacy."
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