Interferon-Gamma for Candida Blood Infection

Phase-Based Progress Estimates
Hellenic Institute for the Study of Sepsis (HISS), Athens, GreeceCandida Blood InfectionInterferon Gamma-1B - Drug
All Sexes
What conditions do you have?

Study Summary

This trial is testing if a drug called rIFN-y is safe and effective in treating patients with candidemia, which is a blood infection.

Treatment Effectiveness

Study Objectives

1 Primary · 12 Secondary · Reporting Duration: through intervention completion, an average at day 11 and 2 and 4 weeks after intervention completion

Day 14
Time to first negative blood culture
Time to treatment success
Study day 14
Adverse events
Sequential Organ Failure Assessment (SOFA) score
Study day 28
Overall survival
Study day 49
Body weight
Number of patients with Treatment Emergent Adverse Events (TEAEs).
Total lymphocytes
Week 4
Percentage of patients with mycological outcomes
Percentage of patients with treatment success

Trial Safety

Safety Progress

2 of 3
This is further along than 68% of similar trials

Trial Design

2 Treatment Groups

Standard of care
1 of 2
1 of 2

Active Control

200 Total Participants · 2 Treatment Groups

Primary Treatment: Interferon-Gamma · No Placebo Group · Phase 2

Standard of careNoIntervention Group · 1 Intervention: Standard of care · Intervention Types:
ActiveComparator Group · 1 Intervention: Interferon Gamma-1B · Intervention Types: Drug

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: through intervention completion, an average at day 11 and 2 and 4 weeks after intervention completion

Who is running the clinical trial?

Radboud University Medical CenterLead Sponsor
1,054 Previous Clinical Trials
570,265 Total Patients Enrolled
Radboud UniversityLead Sponsor
728 Previous Clinical Trials
261,495 Total Patients Enrolled
Horizon 2020 - European CommissionOTHER
26 Previous Clinical Trials
11,983 Total Patients Enrolled
Frank vd Veerdonk, Dr.Principal InvestigatorRadboud University Medical Center

Eligibility Criteria

Age 18+ · All Participants · 7 Total Inclusion Criteria

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Frequently Asked Questions

Are investigators actively looking for participants for this experiment?

"Yes, an examination of the website indicates that this study is actively recruiting patients. According to the information available, the trial was first posted on March 15th, 2022 and was last updated on March 14th, 2022. The research team is looking for 200 individuals to take part in the study at a single site." - Anonymous Online Contributor

Unverified Answer

To the best of your knowledge, does anything like this exist?

"At the moment, there are 9 ongoing studies on Interferon-Gamma being conducted in 13 cities and 8 countries. The first study was completed way back in 2011 by BioMérieux. That particular trial only involved 20 patients, but it did manage to reach Phase 3 approval. In total, 25 studies have been done since then." - Anonymous Online Contributor

Unverified Answer

How many participants are involved in this research project?

"Yes, this research study is looking for volunteers at the moment. The listing was put up on March 15th, 2022 and updated March 14th, 2022. They are trying to find 200 individuals total from one location." - Anonymous Online Contributor

Unverified Answer

Are there any risks that come with treatment by Interferon-Gamma?

"Interferon-Gamma was given a safety score of 2. This is because, although there is data supporting its safety, there is none yet backing up claims of efficacy in Phase 2 trials." - Anonymous Online Contributor

Unverified Answer

Could you give some more examples of where Interferon-Gamma has been used in other medical research?

"Currently, there are 9 different Interferon-Gamma trials underway. 1 of these is in Phase 3. Most of the testing for this treatment is happening in Madison, Wisconsin; however, clinical research regarding Interferon-Gamma is being conducted at 39 different locations." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.