Olanzapine for Opioid Use Disorder
Trial Summary
Will I have to stop taking my current medications?
If you are currently taking any antipsychotic medications, you will need to stop them to participate in this trial. The protocol does not specify about other medications, so it's best to discuss your current medications with the study team.
What data supports the effectiveness of the drug olanzapine for opioid use disorder?
Is olanzapine safe for humans?
Olanzapine is generally considered safe for humans, but it can cause side effects like weight gain, sleepiness, and increased liver enzymes. Rarely, it may lead to serious conditions like diabetic ketoacidosis (a severe diabetes complication) and has been associated with minimal movement disorders. Active monitoring is recommended during treatment.26789
How does the drug olanzapine differ from other treatments for opioid use disorder?
Olanzapine is unique because it is an atypical antipsychotic that can block multiple receptors in the brain, potentially reducing the rewarding effects of opioids like morphine. This makes it different from traditional opioid treatments, which often focus on substituting or blocking opioid receptors directly.1561011
What is the purpose of this trial?
To learn about the effectiveness of taking the antipsychotic medication olanzapine to help lower opioid craving.
Research Team
Joseph Arthur, MD
Principal Investigator
M.D. Anderson Cancer Center
Eligibility Criteria
This trial is for patients who are experiencing pain due to cancer and have been prescribed opioids. It's aimed at those who might be struggling with opioid cravings or misuse.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either olanzapine or placebo for 4 weeks to assess its effect on opioid craving and misuse
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- Olanzapine
Find a Clinic Near You
Who Is Running the Clinical Trial?
M.D. Anderson Cancer Center
Lead Sponsor