This trial is evaluating whether Dapagliflozin 10Mg Tab will improve 1 primary outcome and 3 secondary outcomes in patients with Breast Cancer. Measurement will happen over the course of Through study completion, an average of 1 year..
This trial requires 25 total participants across 1 different treatment group
This trial involves a single treatment. Dapagliflozin 10Mg Tab is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
"The incidence of breast cancer has increased since 1976; however, mortality rates have decreased by 62% during the same period of time. Although aggressive screening methods are being used, the rate of detection is still low; therefore, prevention through lifestyle changes or hormonal replacement therapy can reduce mortality related to breast cancer. More research is needed to decrease the mortality rate." - Anonymous Online Contributor
"Breast cancer is one of the common cancers in women. The incidence of breast cancer has increased over past 30 years. Significant contribution from environmental factors like diet intake, physical activity, smoking etc. is also being noticed. The mortality rates however remain comparatively low. This must be attributed to the aggressive nature of the illness." - Anonymous Online Contributor
"The evidence suggests that there are multiple risk factors. The tryptophan metabolism hypothesis is based mainly on animal studies; however, a recent meta-analysis suggests that there may be no association between the 5HTTLPR polymorphism and breast cancer risk. There is evidence supporting an association between obesity and breast cancer risk, but this requires confirmation." - Anonymous Online Contributor
"Data from a recent study showed that the lifetime risk of getting breast cancer is highest at age 50, and then decreases steadily until age 90. However, because there were relatively few people who got breast cancer before age 40, we weren't able to estimate the average age that breast cancer happens at this young age.\n" - Anonymous Online Contributor
"The current standard for staging and classifying breast cancers is based on tumor size and grade. However, because large tumors tend to have advanced stages (more distant metastases), it is unclear whether all cases of breast cancer should be staged according to tumor size or other factors such as tumor grade or tumor placement. In addition, because invasive breast cancers tend to have higher prevalence of microvascular invasion, it is not clear whether they should be classified as high grade or low grade. Although the current TNM staging system is a useful guide for determining prognosis and predicting clinical outcomes, further research is needed to understand how different imaging techniques, including MRI and ultrasound, may help to evaluate local tumor extension and metastatic involvement." - Anonymous Online Contributor
"Advanced stage breast cancer is associated with decreased survival compared to localized disease. Even in patients who had undergone mastectomy, advanced stage disease was associated with decreased survival. If metastatic disease occurs, even with adjuvant chemotherapy, the prognosis is poor, as well." - Anonymous Online Contributor
"Dapagliflozin treatment over 12 weeks resulted in significant improvements in HRQOL as measured by all three QoL domains. Results from a recent paper were consistent with previous studies on diabetes patients not receiving SGLT2 inhibitors." - Anonymous Online Contributor
"Dapagliflozin was well tolerated in patients with type 2 diabetes mellitus receiving antidiabetic therapy. The two most common adverse events were hypersensitivity reactions and hypoglycemia." - Anonymous Online Contributor
"Dapagliflozin has demonstrated superiority over other glucose-lowering agents and has been shown to increase insulin sensitivity in patients with type 2 diabetes mellitus (T2DM). The 10 mg dosage provides stability of therapeutic efficacy while improving tolerability compared to the 5 mg dosage used in clinical trials. Recent findings support further investigations into the potential use of dapagliflozin as a treatment option for T2DM." - Anonymous Online Contributor
"Results from a recent clinical trial from this study show that environmental exposures play an important role in [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) development. Furthermore, when compared to non-breast cancers, breast cancer was found to be more prevalent in women having a family history of cancer." - Anonymous Online Contributor
"The U.S. Preventive Services Task Force estimates that there are approximately 1.5 million new cases of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) each year in the US. This estimate is similar to one made by the American Cancer Society. However, this actual number is likely overestimated due to underreporting by health professionals. Because of the large number of newly diagnosed cancers annually, the estimated prevalence of breast cancer is relatively low, suggesting that only a small fraction of prevalent breast cancers are detected or diagnosed each year. These statistics may provide valuable information for public health initiatives aimed at improving detection rates." - Anonymous Online Contributor