Acceptance and Commitment Therapy for Breast Cancer

Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL
Breast CancerAcceptance and Commitment Therapy - Behavioral
Eligibility

Study Summary

This trial is testing whether a type of psychotherapy called Acceptance and Commitment Therapy (ACT) can help reduce fatigue, interference with activities, mood, and cognition in people with metastatic breast cancer (MBC). ACT includes mindfulness exercises (e.g., meditations, performing activities with greater awareness), identifying personal values (e.g., family, work), and engaging in activities consistent with these values. A total of 250 patients will be randomly assigned to either the ACT intervention or an education/support condition. Patients in both conditions will participate in six weekly 50-minute telephone sessions. Outcomes will be assessed at baseline, 2 weeks post

Eligible Conditions
  • Metastatic Breast Cancer

Treatment Effectiveness

Study Objectives

2 Primary · 6 Secondary · Reporting Duration: 2 weeks, 3 months, and 6 months post-intervention

2 weeks post-intervention
Fatigue Interference subscale of Fatigue Symptom Inventory
Functional Assessment of Cancer Therapy-General
PROMIS Ability to Participate in Social Roles and Activities
PROMIS Sleep-related Impairment
Month 6
Change in Fatigue Interference subscale of Fatigue Symptom Inventory
Change in Functional Assessment of Cancer Therapy-General
Change in PROMIS Ability to Participate in Social Roles and Activities
Change in Patient Reported Outcomes Measurement Information System (PROMIS) Sleep-related Impairment

Trial Safety

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

Education/Support
1 of 2
Acceptance and Commitment Therapy
1 of 2

Active Control

Experimental Treatment

250 Total Participants · 2 Treatment Groups

Primary Treatment: Acceptance and Commitment Therapy · No Placebo Group · N/A

Acceptance and Commitment Therapy
Behavioral
Experimental Group · 1 Intervention: Acceptance and Commitment Therapy · Intervention Types: Behavioral
Education/Support
Behavioral
ActiveComparator Group · 1 Intervention: Education/Support · Intervention Types: Behavioral
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Acceptance and Commitment Therapy
2010
Completed Phase 1
~1490

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 2 weeks, 3 months, and 6 months post-intervention

Who is running the clinical trial?

Northwestern UniversityOTHER
1,504 Previous Clinical Trials
866,465 Total Patients Enrolled
35 Trials studying Breast Cancer
11,886 Patients Enrolled for Breast Cancer
Indiana UniversityLead Sponsor
912 Previous Clinical Trials
775,421 Total Patients Enrolled
15 Trials studying Breast Cancer
3,535 Patients Enrolled for Breast Cancer
National Cancer Institute (NCI)NIH
13,280 Previous Clinical Trials
41,234,804 Total Patients Enrolled
932 Trials studying Breast Cancer
1,541,944 Patients Enrolled for Breast Cancer
Eskenazi HealthOTHER
8 Previous Clinical Trials
2,124 Total Patients Enrolled
1 Trials studying Breast Cancer
375 Patients Enrolled for Breast Cancer
Community Health NetworkOTHER
5 Previous Clinical Trials
1,215,342 Total Patients Enrolled
Indiana University HealthOTHER
26 Previous Clinical Trials
14,021 Total Patients Enrolled
2 Trials studying Breast Cancer
466 Patients Enrolled for Breast Cancer
Catherine E Mosher, Ph.D.Principal InvestigatorIndiana University
1 Previous Clinical Trials
84 Total Patients Enrolled

Eligibility Criteria

Age 18+ · Female Participants · 1 Total Inclusion Criteria

Mark “Yes” if the following statements are true for you:
You experience significant tiredness that affects your ability to do everyday activities.

Frequently Asked Questions

Are there still opportunities to join this experimental research?

"Affirmative. Data available on clinicaltrials.gov reveals that this scientific experiment, initially posted in June of 2019, is actively seeking participants. Approximately 250 individuals must be recruited from a single research facility." - Anonymous Online Contributor

Unverified Answer

What is the current enrollment size of this experiment?

"Affirmative, the contents on clinicaltrials.gov demonstrate that this medical experiment is actively recruiting volunteers. It was initially announced on June 20th 2019 and has been edited as of December 29 2021. The study requires 250 participants from one location." - Anonymous Online Contributor

Unverified Answer

Has the FDA confirmed the efficacy of Acceptance and Commitment Therapy?

"This treatment is backed by preliminary safety evidence, resulting in an estimated score of 2. Unfortunately, there are no available studies which have looked at the efficacy of Acceptance and Commitment Therapy at this time." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.