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Chemotherapy

HER2-negative, including TNBC or HR-positive for Breast Cancer

Phase 2
Waitlist Available
Led By Maryann Kwa
Research Sponsored by NYU Langone Health
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 1 year
Awards & highlights

Study Summary

This trialstudied if nivolumab could help fight invasive breast cancer before it spreads.

Eligible Conditions
  • Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 1 year
This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 1 year for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Number of Participants Who Had a Pathological Complete Response (pCR)

Trial Design

2Treatment groups
Experimental Treatment
Group I: HER2-positive, independent of HR statusExperimental Treatment6 Interventions
Group II: HER2-negative, including TNBC or HR-positiveExperimental Treatment4 Interventions
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Doxorubicin 60mg/m^2
2019
Completed Phase 2
~10
Cyclophosphamide 600mg/m^2
2019
Completed Phase 2
~10
Paclitaxel 80mg/m^2 or Docetaxel 75mg/m^2
2019
Completed Phase 2
~10
Nivolumab 360mg
2019
Completed Phase 2
~10
Paclitaxel 80mg/m^2
2019
Completed Phase 2
~10
Trastuzumab 8mg/kg and 6 mg/kg
2019
Completed Phase 2
~10
Pertuzumab 840mg and 420mg
2019
Completed Phase 2
~10

Find a Location

Who is running the clinical trial?

NYU Langone HealthLead Sponsor
1,366 Previous Clinical Trials
839,710 Total Patients Enrolled
37 Trials studying Breast Cancer
7,259 Patients Enrolled for Breast Cancer
Maryann KwaPrincipal InvestigatorNYU Langone Health

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What treatments are typically prescribed for HER2-negative, including TNBC or HR-positive patients?

"HER2-negative, including TNBC or HR-positive has been used to treat numerous forms of lung cancer. This medication is also frequently employed in the treatment of unresectable melanoma, squamous cell carcinoma, and small cell lung cancer (SCLC)."

Answered by AI

Has the FDA approved any drugs to treat HER2-negative, TNBC or HR-positive conditions?

"Based on the available evidence, our team at Power estimates that HER2-negative and TNBC or HR-positive has a safety rating of 2. Though there is limited clinical data demonstrating its efficacy, some research points to potential safety outcomes."

Answered by AI

Can you elaborate on other experiments that have taken place involving HER2-negative, including TNBC or HR-positive patients?

"Initially, Spectrum Health Hospital - Butterworth Campus investigated HER2-negative illnesses such as TNBC or HR-positive in 1997. Subsequently, 3474 clinical trials have been completed and 2669 are presently ongoing at medical centres across the nation; a majority of which are located in New york City."

Answered by AI

Does this research project break new ground?

"Presently, 2669 studies focusing on HER2-negative TNBC or HR-positive are being conducted around the world. Across 82 countries and 4442 cities, researchers have been exploring this topic since Alfacell's 1997 trial of 300 subjects which culminated in Phase 3 drug approval. Since then, 3474 trials have concluded their research endeavors."

Answered by AI

Are participants welcome to join the experiment presently?

"This research is not actively seeking participants at this moment. It was first posted on the 2nd of May 2019, and it's most recent update happened on 21st October 2022. If you are looking for additional medical studies, presently there are 2603 trials that target breast cancer patients and 2669 clinical investigations targeting HER2-negative or HR+ individuals who struggle with TNBC recruiting individuals."

Answered by AI

What is the scope of participant recruitment for this experiment?

"This research trial has expired and is no longer accepting volunteers. It was first posted on May 2nd, 2019 before being updated for the last time in October 21st 2022. If you are seeking alternative studies to join, there are currently 2603 trials recruiting participants with breast cancer and 2669 investigations looking for individuals suffering from HER2-negative including TNBC or HR-positive diseases."

Answered by AI
~1 spots leftby Apr 2025