APBI: 30 Gy for Breast Cancer
This study is evaluating whether a higher dose of radiation might be better for women with breast cancer.
See full descriptionAbout the trial for Breast Cancer
Treatment Groups
This trial involves 2 different treatments. APBI: 30 Gy is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 2 and have already been tested with other people.
Eligibility
This trial is for female patients aged 18 and older. There are 3 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether APBI: 30 Gy will improve 1 primary outcome and 5 secondary outcomes in patients with Breast Cancer. Measurement will happen over the course of 12, 24, 36 and 60 months.
Patient Q & A Section
What are the signs of breast cancer?
The signs of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) include a lump in the breast, nipple discharge, a tingling, an abnormally firm or mobile breast, pain in the bone of the breast, and a lump in the armpit. Although these symptoms can appear without breast cancer, they are often present for other reasons and are usually not specific to the disease. If a lump persists after six months of an otherwise benign breast infection, it is cause for concern. The more worrisome signs arise after the lump has become larger and painful, and when changes are seen in part of the lymph nodes on the side of the infirm, such as a swollen, erythematous, or edematous lymph node.
What is breast cancer?
This short film illustrates the common symptoms of breast cancer, its consequences, the treatments available, the benefits of screening and the implications of screening and treatment in women of all backgrounds.
Can breast cancer be cured?
The study concluded that the data suggests there is an opportunity for eliminating breast cancer, but further research is needed before any action can be undertaken. Results from a recent clinical trial of this study are encouraging, but we need more sophisticated technology in order to implement the method.
What are common treatments for breast cancer?
The most common breast cancer treatment is surgery, which is typically used in combination with chemotherapy and/or hormone therapy. Other treatments may include tamoxifen and taxane chemotherapy. Treatment options vary by tumor subtype. Patients who have luminal A breast cancer are more likely to benefit from neoadjuvant chemotherapy as adjuvant chemotherapy should be given after lumpectomy. Patients who have triple-negative breast cancer are more likely to receive mastectomy surgery and adjuvant chemotherapy. Clinicians should consider the treatment options required for their patient and/or treatment plan.
What causes breast cancer?
Approximately 90% of all [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) cases arise from one of two mammary morphologic subtypes. The vast majority of invasive cancers have lost their expression of estrogen receptor. This loss appears to be independent of age, sex, age at menopause or radiation exposure. Although the mechanisms of progression are still unknown, the hormone hypothesis of carcinogenesis suggests the possible roles of estrogens and progesterone as key components of breast cancer pathogenesis.
How many people get breast cancer a year in the United States?
About 100,000 women get [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) in the United States to each year. It is the most common cancer in women in the United States.
How quickly does breast cancer spread?
The 5-year interval from diagnosis to distant metastasis is one of the best and most useful predictors of disease progression after breast cancer treatment by mastectomy. Because distant metastasis is the most common cause of breast cancer-related death, careful follow-up should be performed.
What is the primary cause of breast cancer?
It is known that radiation plays an important role in the development of [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) and it is also an important cause of secondary cancers. There are many hypotheses that try to explain the relationship between the exposure to radiation and the primary causes of breast cancer, but there is not sufficient evidence to help us pinpoint the main cause of the disease.
Has apbi: 30 gy proven to be more effective than a placebo?
The data do not show improved disease free survival in this patient population after a conservative treatment scheme using a high grade, but intermediate dose BBI (30 Gy), compared to a placebo of 30 Gy.
What is the average age someone gets breast cancer?
In the United States, the current average age at diagnosis is 49.4 years, although it is higher in more developed settings. This data has been previously used to determine the age of diagnosis for [metastatic [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer)](https://www.withpower.com/clinical-trials/metastatic-breast-cancer). As the cancer tends to be more aggressive as it progresses, treatment tends to be more aggressive as well, so people who get breast cancer at a young age have a higher rate of dying from the disease than when it is diagnosed at a mid-age.
Have there been other clinical trials involving apbi: 30 gy?
In a recent study, findings provides the first evidence of a reduced recurrence and survival time when radiotherapeutic techniques are performed prior to surgery in women with Stage IV breast cancer.