This trial is evaluating whether Aspirin will improve 1 primary outcome and 4 secondary outcomes in patients with Node Positive HER2 Negative Breast Cancer. Measurement will happen over the course of Time from randomization to first occurrence of any one of the following: distant recurrence, locoregional recurrence, ipsilateral or contralateral breast cancer, second primary (non-breast) invasive cancer or death or any cause, assessed up to 5 years.
This trial requires 3021 total participants across 2 different treatment groups
This trial involves 2 different treatments. Aspirin is the primary treatment being studied. Participants will all receive the same treatment. Some patients will receive a placebo treatment. The treatments being tested are in Phase 3 and have had some early promising results.
"Overall, patients are optimistic about their chances of being cured. Patients and their families often want curative treatment, but patients' desire for curative treatment may be motivated to avoid the risks of medical treatment." - Anonymous Online Contributor
"The cause of this cancer is unclear. Some environmental, genetic and hormonal factors have been implicated. It may also be a consequence of cancer cells spreading to other parts of the body. There is a possibility that risk is higher among survivors of breast cancer, but no strong evidence for that has been found.\n" - Anonymous Online Contributor
"Many people with [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) do not have any symptoms at diagnosis. Others may complain of pain in the chest or over the breast. Nipple discharge is often a result of breast cancer, but may also be due to other health problems. A lump in the breast may be a sign of breast cancer. Other signs and symptoms of breast cancer include lump, thickening or dimpling of the nipple, redness or sores around a nipple, lump in the breast that does not disappear or itch.\nSymptoms of testicular cancer involve the formation of a lump near the testicles, swelling around the testicles or pain or numbness in the scrotum." - Anonymous Online Contributor
"Breast cancer is often treated with hormone replacement therapy and surgery. Chemotherapy, radiotherapy, and targeted therapy are sometimes used. These treatments can contribute to the cancer's effectiveness." - Anonymous Online Contributor
"The US prevalence of breast cancer is substantially lower than that of other industrialized nations. Because there are several factors that may lead to a delay in the diagnosis of breast cancer, the observed differences in the prevalence of breast cancer between different industrialized nations may be influenced by differences in the proportions of women with risk factors for breast cancer." - Anonymous Online Contributor
"Breast cancer is a cancer that forms in the breasts and typically forms in women over 50 years of age. Diagnosis is typically made through mammograms undertaken for other reasons. It is the most common type of cancer in women in developed countries, accounting for approximately 25% of all cancers in women." - Anonymous Online Contributor
"New treatments have been developed in recent years that have shown to be more effective but also have several disadvantages in their use for breast cancer treatment. Therefore, the ultimate treatment selection depends on a comprehensive review of the situation of the patient." - Anonymous Online Contributor
"The new research has improved treatment options and diagnostic tests for cancers and their precursors. At the same time they have raised questions about diagnosis, prevention and treatment. Even though there is no guarantee that the latest research will improve the 5-year survival, it is sure that there is hope for the future, because of the work being done by the leaders in science and medicine question: Do breast cancer treatment guidelines need to update? answer: Breast cancer has been revised as a disease for a number of years, and this is likely to be the case as more evidence shows that the optimal management is disputed. However there is no indication that this situation will change in the foreseeable future." - Anonymous Online Contributor
"The average age that someone gets [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer) is 50 years. A little older than average has been reported as 47 yr. It is important to have periodic mammograms and have these tests as early as possible so as to detect cancer when it is manageable and to give the patient options on treatment options." - Anonymous Online Contributor
"For breast cancer patients with hormone-resistance, this study suggests that aspirin plus chemo-herbal therapy may provide survival benefit comparable to that of endocrine therapy with tamoxifen alone or chemo-endocrine therapy with tamoxifen/aromatase inhibitor." - Anonymous Online Contributor
"Although it is sometimes touted that aspirin prevents both colorectal and [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer), in the real world, aspirin’s effectiveness is most commonly associated with preventing colorectal adenomas and cancers. More than 30% of the people taking aspirin to prevent colon cancer will eventually develop cancer. Currently, NSAID only is a preventive or therapeutic option in a very small minority of breast cancer patients. Breast cancer usually does not respond to NSAID-only or chemo-only treatment. The combination of NSAID and chemo usually will cause even more side effects as well as increased risk over time. It may take almost 5 years to see any positive effects with NSAID alone use." - Anonymous Online Contributor
"Although the use of this medication increased between years 1999 and 2007, there still remain many uncertainties regarding its use in [breast cancer](https://www.withpower.com/clinical-trials/breast-cancer). This is because it is often used with chemotherapy. Breast cancer patients in this cohort are less likely to be able to obtain benefit from this medications use. The use of aspirin was more common for patients with node-negative cancer. The use of this therapy was also commonly associated with paclitaxel (taxol), a chemotherapy drug being used for breast cancer patients." - Anonymous Online Contributor