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Aspirin for Breast Cancer

Phase 3
Waitlist Available
Research Sponsored by Alliance for Clinical Trials in Oncology
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 5 years
Awards & highlights

Study Summary

This trial will study whether aspirin can help prevent breast cancer from coming back after chemotherapy, surgery, and/or radiation therapy.

Eligible Conditions
  • Node Positive HER2 Negative Breast Cancer

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~5 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 5 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Median Invasive Disease-free Survival (iDFS)
Secondary outcome measures
Incidence of Cardiovascular Disease (Including Cerebrovascular Events, Myocardial Infarction, or Coronary Artery Disease Requiring Stent Placement, Angioplasty, or Bypass Surgery)
Incidence of Toxicities, Graded Using the National Cancer Institute's Common Terminology Criteria for Adverse Events Version 4.3
Median Distant Disease Free Survival (DDFS)
+1 more

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm I (aspirin)Experimental Treatment1 Intervention
Patients receive aspirin PO QD for five years in the absence of disease progression or unacceptable toxicity.
Group II: Arm II (Placebo)Placebo Group1 Intervention
Patients receive placebo PO QD for five years in the absence of disease progression or unacceptable toxicity.
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Aspirin
2014
Completed Phase 4
~55580

Find a Location

Who is running the clinical trial?

Alliance for Clinical Trials in OncologyLead Sponsor
512 Previous Clinical Trials
214,617 Total Patients Enrolled
75 Trials studying Breast Cancer
40,143 Patients Enrolled for Breast Cancer
National Cancer Institute (NCI)NIH
13,660 Previous Clinical Trials
40,921,627 Total Patients Enrolled
940 Trials studying Breast Cancer
1,543,360 Patients Enrolled for Breast Cancer
United States Department of DefenseFED
863 Previous Clinical Trials
224,611 Total Patients Enrolled
37 Trials studying Breast Cancer
3,466 Patients Enrolled for Breast Cancer

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For what common ailment is Aspirin usually given to patients?

"Aspirin has a variety of uses, such as reducing inflammation, managing pain, and preventing blood clotting during dental procedures and pci."

Answered by AI

Is it dangerous to take aspirin regularly?

"Aspirin is a Phase 3 trial drug, which means that while there is some data supporting efficacy, there are multiple rounds of data supporting safety. Therefore, our team at Power has estimated the safety of Aspirin to be a 3."

Answered by AI

Are there any vacancies in this particular clinical trial?

"Unfortunately, this particular study is not presently looking for patients to participate. The trial was initially posted on December 8th, 2016 and was last updated January 6th, 2022. There are, however, 2,538 other trials that are recruiting patients."

Answered by AI

Will this be the first time this research is conducted?

"Aspirin clinical trials began in 2002 with Sanofi as the primary sponsor. The first Phase 3 trial had 413 participants and aspirin was approved for general use after this point. As of now, there are 181 active aspirin studies being conducted in 61 countries and 1451 cities."

Answered by AI

How can I become involved in this experiment?

"Those with malignant neoplasms who are also within the ages of 18 and 69 may qualify for this clinical trial. Currently, the study is looking for 3021 individuals."

Answered by AI

Does this clinical trial have an age limit for participants?

"In order to be eligible for this trial, applicants must fall between the ages of 18 to 69. For context, there are 80 different trials underway for treatments targeting those under 18 and 2441 for those over the age of 65."

Answered by AI

In how many different medical centers is this research project being conducted presently?

"There are 100 sites where this clinical trial is offered, such as University of Kansas Cancer Center - North in Kansas City, Lowell General Hospital in Lowell, and Saint Francis Regional Medical Center in Shakopee."

Answered by AI

What is the history of research involving Aspirin?

"In 2002, at Institut Curie Hopital, aspirin was first studied. Since that time, there have been 18,677 completed clinical trials. As of now, there are 181 active medical studies, a majority of which are based in Kansas City, Missouri."

Answered by AI

Is there a limit to the amount of people who can enroll in this clinical trial?

"Unfortunately, this trial is not recruiting at this moment. However, there are 2357 trials for patients with malignant neoplasms and 181 studies for patients taking Aspirin."

Answered by AI

Who else is applying?

What state do they live in?
Texas
New York
Other
Indiana
How old are they?
18 - 65
What site did they apply to?
IU Health Ball Memorial Hospital
New York-Presbyterian/Brooklyn Methodist Hospital
Austin Cancer Centers-Northwest
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
How many prior treatments have patients received?
0
~363 spots leftby Apr 2025