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Taxane
Docetaxel + Estramustine for Breast Cancer
Phase 2
Waitlist Available
Research Sponsored by Herbert Irving Comprehensive Cancer Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial Must have
Hepatic: Bilirubin less than the upper limit of normal, SGOT or SGPT less than 1.5 times normal
No visible metastases on brain CT or MRI (unless single lesion amenable to surgical resection)
Timeline
Screening 3 weeks
Treatment Varies
Follow Up up to 5 years
Awards & highlights
Study Summary
This trial is studying how well docetaxel and estramustine work in treating women with metastatic breast cancer.
Who is the study for?
This trial is for women with metastatic breast cancer that can be measured or evaluated. Participants should not qualify for other high-priority studies and must have no visible brain metastases, unless it's a single lesion that can be surgically removed.Check my eligibility
What is being tested?
The study is testing the effectiveness of combining two chemotherapy drugs, docetaxel and estramustine, to see if they are better together at stopping the growth or causing the death of tumor cells in women with advanced breast cancer.See study design
What are the potential side effects?
Possible side effects may include nausea, hair loss, fatigue, increased risk of infection due to low blood cell counts, mouth sores, and allergic reactions. The combination might also increase these risks compared to taking each drug alone.
Eligibility Criteria
Inclusion Criteria
You may be eligible if you check “Yes” for the criteria belowSelect...
My liver tests are within normal ranges.
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I don't have visible brain metastases, or I have only one that can be surgically removed.
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I am able to get out of my bed or chair and move around.
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My blood counts are healthy and I don't have a clotting disorder, or it's treated.
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My cancer can be measured or seen on tests.
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I am over 18 years old.
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I am female.
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I have had no cancer before, except for treated skin or cervical cancer.
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My kidney function tests are within normal limits.
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I have not had a blood clot, or if I did, I am on blood thinners.
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I do not have swelling or fluid buildup in my abdomen, chest, or limbs.
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My breast cancer has spread and was confirmed by a tissue test.
Timeline
Screening ~ 3 weeks3 visits
Treatment ~ Varies
Follow Up ~ up to 5 years
Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~up to 5 years
Treatment Details
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Who is running the clinical trial?
Herbert Irving Comprehensive Cancer CenterLead Sponsor
34 Previous Clinical Trials
1,049 Total Patients Enrolled
4 Trials studying Breast Cancer
280 Patients Enrolled for Breast Cancer
Amy D. Tiersten, MDStudy ChairHerbert Irving Comprehensive Cancer Center
5 Previous Clinical Trials
159 Total Patients Enrolled
Media Library
Eligibility Criteria:
This trial includes the following eligibility criteria:- It's been over 4 weeks since my last standard chemotherapy, or 2 weeks if it was a weekly treatment.My liver tests are within normal ranges.My hormone receptor status is not specified.I don't have visible brain metastases, or I have only one that can be surgically removed.I have had hormone therapy for my condition.It has been over 4 weeks since my last radiation treatment.I am able to get out of my bed or chair and move around.My blood counts are healthy and I don't have a clotting disorder, or it's treated.My cancer can be measured or seen on tests.I am over 18 years old.I am female.I do not have any severe health or mental health conditions.I have had no cancer before, except for treated skin or cervical cancer.My kidney function tests are within normal limits.I have not had a blood clot, or if I did, I am on blood thinners.I do not have swelling or fluid buildup in my abdomen, chest, or limbs.My treatment plan does not specify biologic therapy.It has been over a week since my last surgery.My breast cancer has spread and was confirmed by a tissue test.
Research Study Groups:
This trial has the following groups:Awards:
This trial has 1 awards, including:- No Placebo-Only Group - All patients enrolled in this study will receive some form of active treatment.
Timeline:
This trial has the following timeline:- Screening: It may take up to 3 Weeks to process to see if you qualify in this trial.
- Treatment: The duration you will receive the treatment varies.
- Follow Ups: You may be asked to continue sharing information regarding the trial for 6 Months after you stop receiving the treatment.
Frequently Asked Questions
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Are new participants able to join this research endeavor at the present time?
"Clinicaltrials.gov suggests that this clinical trial, which went live on February 1st 1997 is no longer accepting participants. Despite its inactivity, 2600 other trials are still actively recruiting patients."
Answered by AI
Could you please elucidate the potential hazards associated with this treatment?
"Due to the lack of clinical evidence demonstrating its effectiveness, we rate this treatment's safety as a 2 on our scale. The Phase 2 trial provides some assurance that it is safe but not effective."
Answered by AI
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