Radiosurgery Three Treatments for Brain Metastases

University Of Chicago, Chicago, IL
Brain Metastases+1 More ConditionsRadiosurgery Three Treatments - Radiation
All Sexes

Study Summary

This trial is comparing different ways to do surgery for brain cancer.

Eligible Conditions
  • Cancer Brain Metastases
  • Metastatic Brain Tumors

Treatment Effectiveness

Phase-Based Effectiveness

1 of 3
Phase 2

Study Objectives

1 Primary · 9 Secondary · Reporting Duration: 4 years

1 year
Rates of Symptomatic Edema
4 years
Acute CTCAE v5.0 CNS Grade 2+ and Grade 3+ toxicities
Late CTCAE v5.0 CNS Grade 2+ and Grade 3+ toxicities
Multi-Fraction SRS superiority compared to single fraction SRS
Overall Survival Rate
Target metastasis progression
Time to any distant intracranial failure
Time to initiation of any combination
rate of individual metastases radionecrosis
rate of individual metastases rates of edema

Trial Safety

Phase-Based Safety

2 of 3
This is further along than 68% of similar trials

Awards & Highlights

No Placebo Group
All patients enrolled in this trial will receive the new treatment.

Trial Design

2 Treatment Groups

1 of 2
Arm A
1 of 2

Active Control

Experimental Treatment

74 Total Participants · 2 Treatment Groups

Primary Treatment: Radiosurgery Three Treatments · No Placebo Group · Phase 2

Arm A
Experimental Group · 1 Intervention: Radiosurgery Three Treatments · Intervention Types: Radiation
ActiveComparator Group · 1 Intervention: Radiosurgery Single Treatment · Intervention Types: Radiation

Trial Logistics

Trial Timeline

Screening: ~3 weeks
Treatment: Varies
Reporting: 4 years

Who is running the clinical trial?

University of ChicagoLead Sponsor
951 Previous Clinical Trials
759,486 Total Patients Enrolled
Steven Chmura, MDPrincipal InvestigatorUniversity of Chicago
4 Previous Clinical Trials
187 Total Patients Enrolled

Eligibility Criteria

Age 18+ · All Participants · 0 Total Inclusion Criteria

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Frequently Asked Questions

Could you describe what safety precautions are in place for those undergoing Radiosurgery Three Treatments?

"The safety of radiosurgery three treatments was estimated to be 2, as this is a phase two trial and there exists evidence backing its security but none verifying its effectiveness." - Anonymous Online Contributor

Unverified Answer

How many participants has this study recruited thus far?

"Affirmative, the details posted on indicate that this investigation is recruiting participants now. This research was first published to the website on June 29th 2020 and has been updated most recently on September 14th 2021. The study requires 74 subjects at one location." - Anonymous Online Contributor

Unverified Answer

Are there any vacancies for people to partake in this experiment?

"Correct. The details uploaded to demonstrate that this medical study, which was initially announced on June 29th 2020, is presently seeking patients. 74 eligible subjects need to be found from a single facility." - Anonymous Online Contributor

Unverified Answer
Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.