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Bisphosphonates

1 for Human Immunodeficiency Virus Infection

Phase 2
Waitlist Available
Led By Jeannie S. Huang, MD, MPH
Research Sponsored by National Institute of Allergy and Infectious Diseases (NIAID)
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up throughout study
Awards & highlights

Study Summary

Bisphosphonates are a type of drug used to prevent and treat bone loss. The purpose of this study is to determine if zoledronate, an investigational bisphosphonate, can improve bone mineral density (BMD) in HIV-infected adults. Study hypothesis: Zoledronate will reduce bone resorption in HIV-infected persons with osteopenia.

Eligible Conditions
  • Human Immunodeficiency Virus Infection
  • Osteopenia
  • Osteoporosis

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~throughout study
This trial's timeline: 3 weeks for screening, Varies for treatment, and throughout study for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Bone metabolic markers
Secondary outcome measures
Safety outcomes

Side effects data

From 2008 Phase 2 trial • 68 Patients • NCT00213980
41%
Hot Flash
16%
Myalgia
13%
Fatigue
13%
Pain
9%
Arthralgia
6%
Edema
100%
80%
60%
40%
20%
0%
Study treatment Arm
Observation
Zoledronic Acid (ZA)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: 1Experimental Treatment1 Intervention
Participants will receive zoledronate at study entry; their assigned intervention will be given in a 20- to 30-minute infusion on an outpatient basis
Group II: 2Placebo Group1 Intervention
Participants will receive zoledronate placebo at study entry; their assigned intervention will be given in a 20- to 30-minute infusion on an outpatient basis
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Zoledronic acid
FDA approved

Find a Location

Who is running the clinical trial?

National Institute of Allergy and Infectious Diseases (NIAID)Lead Sponsor
3,269 Previous Clinical Trials
5,481,439 Total Patients Enrolled
Jeannie S. Huang, MD, MPHPrincipal InvestigatorUniversity of California, San Diego

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Bisphosphonate Therapy for HIV-Infected Adults With Decreased Bone Mineral Density
2005. "Bisphosphonate Therapy for HIV-Infected Adults With Decreased Bone Mineral Density". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00102908.
All > Cte
~2 spots leftby Apr 2025
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