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Anticonvulsant

DVP + Quetiapine for Schizophrenia

Phase 3
Waitlist Available
Led By Trisha Suppes, MD, PhD
Research Sponsored by Palo Alto Veterans Institute for Research
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up week 12
Awards & highlights

Study Summary

This study will determine the effectiveness of three different drug therapies in treating the symptoms of mania.

Eligible Conditions
  • Schizophrenia
  • Bipolar Disorder

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~week 12
This trial's timeline: 3 weeks for screening, Varies for treatment, and week 12 for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Symptoms of Mania, as Measured by Young Mania Rating Scale
Secondary outcome measures
Clinical Global Impression Scale for Bipolar Disorder (CGI-BD)
Global Assessment of Functioning
Mental Depression
+1 more

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: DVP + QuetiapineActive Control2 Interventions
Participants will receive divalproex ER at a therapeutic dose, plus quetiapine up to 800 mg
Group II: DVP + LithiumActive Control2 Interventions
Participants will receive divalproex ER at a therapeutic dose, plus lithium at a therapeutic blood level
Group III: DVP + placeboPlacebo Group1 Intervention
Participants will receive divalproex ER at a therapeutic dose, plus placebo

Find a Location

Who is running the clinical trial?

Palo Alto Veterans Institute for ResearchLead Sponsor
52 Previous Clinical Trials
7,830 Total Patients Enrolled
1 Trials studying Schizophrenia
National Institute of Mental Health (NIMH)NIH
2,796 Previous Clinical Trials
2,689,486 Total Patients Enrolled
250 Trials studying Schizophrenia
89,386 Patients Enrolled for Schizophrenia
Trisha Suppes, MD, PhDPrincipal InvestigatorStanford School of Medicine and VA Palo Alto Health Care System
3 Previous Clinical Trials
181 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Treatment of Mania Symptoms With Drug Therapy
Patricia Suppes 2005. "Treatment of Mania Symptoms With Drug Therapy". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT00183443.
~4 spots leftby May 2025
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