Study Summary
This trial is testing a new combination treatment for advanced biliary tract cancer.
- Biliary Tract Cancer
Treatment Effectiveness
Effectiveness Progress
Study Objectives
1 Primary · 2 Secondary · Reporting Duration: From the time of randomization until death, up to approximately 5 years
Trial Safety
Safety Progress
Side Effects for
Trial Design
2 Treatment Groups
DKN 01 and Nivolumab
1 of 2
DKN 01 and Nivolumab Safety Run in
1 of 2
Experimental Treatment
30 Total Participants · 2 Treatment Groups
Primary Treatment: DKN-01 · No Placebo Group · Phase 2
Trial Logistics
Trial Timeline
Who is running the clinical trial?
Eligibility Criteria
Age 18+ · All Participants · 21 Total Inclusion Criteria
Mark “Yes” if the following statements are true for you:Frequently Asked Questions
How many individuals are included in this research?
"That is correct. The latest information from clinicaltrials.gov says that this study, which began recruitment on October 7th 2019, is still looking for candidates. They need 30 people total, at 2 different locations." - Anonymous Online Contributor
What is the DKN-01 drug's official standing with the FDA?
"DKN-01 has not yet been proven effective, however, there is some data supporting its safety which gives it a ranking of 2." - Anonymous Online Contributor
Is this research novel in any way?
"DKN-01 has a long history, with the first clinical study being performed a decade ago in 2010. The original trial was sponsored by Medarex and only involved 127 patients. DKN-01 received Phase 1 approval after this initial study. As of now, there are 747 active studies involving DKN-01 located in 2347 cities across 50 countries." - Anonymous Online Contributor
Are investigators actively looking for participants for this research project?
"The trial is currently recruiting patients, as indicated by the information on clinicaltrials.gov. This study was originally posted on October 7th, 2019 and has been edited recently on January 24th, 2021." - Anonymous Online Contributor
What other data is available on DKN-01?
"Currently, there are 747 clinical trials studying DKN-01. 82 of those live clinical trials are in Phase 3. While the many trials for DKN-01 are based in Basel, BE, there are 40324 locations running studies for this treatment." - Anonymous Online Contributor
What is the primary reason that DKN-01 is prescribed?
"DKN-01 is most often used to treat malignant neoplasms, but it can also be prescribed for conditions like metastatic esophageal adenocarcinoma, squamous cell carcinoma, and unresectable melanoma." - Anonymous Online Contributor