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Antipyrine-benzocaine otic solution for Asthma (CREWS01 Trial)

Phase 2

Waitlist Available

Led By John D Prosser, MD

Research Sponsored by Global United Pharmaceutical Corporation

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up each participant is studied for four weeks

Awards & highlights

CREWS01 Trial Summary

This trialtests if blocking a nerve in the ear can improve asthma symptoms & reduce reliance on rescue inhalers without harming lung function.

CREWS01 Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ each participant is studied for four weeks

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~each participant is studied for four weeks

This trial's timeline: 3 weeks for screening, Varies for treatment, and each participant is studied for four weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Efficacy of CREWS01 (topical auricular anesthesia of the vagus nerve) to decrease usage of rescue inhalers in moderate to severe asthmatic adults Change in usage of rescue inhalers in moderate to severe asthmatic adults in four weeks

Secondary outcome measures

Improvement of spirometry scores in moderate to severe asthmatic adults

Other outcome measures

Evaluate the safety of using topical anesthetics in moderate to severe asthmatic adults

CREWS01 Trial Design

2Treatment groups

Active Control

Placebo Group

Group I: Antipyrine-benzocaine otic solutionActive Control1 Intervention

Will be used on 50% of participants, we anticipate reduction in the usage of rescue inhalers, spirometer scores, asthma diaries, and expired fractionated nitrous oxide levels.

Group II: Glycerin with Oxyquinoline SulfatePlacebo Group1 Intervention

For those participants who receive glycerin with oxyquinoline sulfate placebo, we do not anticipate any change in the usage of rescue inhalers, spirometer scores, asthma diaries, and expired fractionated nitrous oxide levels.

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Who is running the clinical trial?

Global United Pharmaceutical CorporationLead Sponsor

John D Prosser, MDPrincipal InvestigatorAugusta University

Anthony C Hughes, MDPrincipal InvestigatorAugusta University

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

For what clinical reasons is Antipyrine-benzocaine otic solution prescribed?

"Antipyrine-benzocaine otic solution is a therapeutic option for treating haemorrhoids, and it can additionally be used to relieve cold symptoms, sunburns, or numb areas during medical treatments."

Answered by AI

Can individuals still be enrolled in this research experiment?

"According to the clinicaltrials.gov website, no new participants are being sought for this study which initially posted on July 1st 2014 and updated two months later. Although closed, 319 other medical studies remain open and recruiting patients at present."

Answered by AI

Has the FDA approved Antipyrine-benzocaine otic solution for use?

"Our team at Power has assigned Antipyrine-benzocaine otic solution a safety rating of 2 due to the presence of supportive data from Phase 2 trials, but no evidence for efficacy."

Answered by AI

Are there any related investigations into the effects of Antipyrine-benzocaine otic solution?

"Currently, two clinical trials are underway for the Antipyrine-benzocaine otic solution with no Phase 3 studies being conducted. The majority of these research projects take place in Augusta, Georgia but there is also involvement from three additional sites."

Answered by AI

How many participants are currently receiving treatment as part of this research?

"At this time, recruitment for this trial is no longer occurring. This study was initially published on July 1st 2014 and its information was last updated on June 2nd 2014. For those looking to join a medical trial related to asthma, 317 studies are presently recruiting participants while there are two trials searching for patients with Antipyrine-benzocaine otic solution."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Assessing the Efficacy of CREWS01 to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults

2023. "Assessing the Efficacy of CREWS01 to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02153541.