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Anti-metabolites

Arm B for Anal Squamous Cell Carcinoma (InterAACT Trial)

Phase 2
Waitlist Available
Led By Sheela Rao, MD, FRCP
Research Sponsored by Royal Marsden NHS Foundation Trust
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 3 years
Awards & highlights

InterAACT Trial Summary

Anal cancer is a relatively uncommon disease and there is currently no standard chemotherapy treatment for patients with inoperable locally recurrent or metastatic disease. The aim of this phase II study is compare two well known and largely used chemotherapy regimens - Cisplatin plus 5-fluorouracil vs Carboplatin plus Paclitaxel. The result of this study will set a standard of care for this disease and provide useful information for future Phase III trials.

Eligible Conditions
  • Anal Squamous Cell Carcinoma

InterAACT Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~3 years
This trial's timeline: 3 weeks for screening, Varies for treatment, and 3 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Best overall response rate by 24 weeks post treatment
Secondary outcome measures
Anti-tumour activity and magnitude of tumour response
Best overall response rate of non-irradiated lesions
Disease control rate
+6 more

InterAACT Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Arm BExperimental Treatment2 Interventions
Carboplatin plus Paclitaxel
Group II: Arm AActive Control2 Interventions
Cisplatin and 5-Fluorouracil
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Carboplatin
FDA approved
Paclitaxel
FDA approved

Find a Location

Who is running the clinical trial?

Royal Marsden NHS Foundation TrustLead Sponsor
308 Previous Clinical Trials
10,123,401 Total Patients Enrolled
Cancer Research UKOTHER
256 Previous Clinical Trials
4,434,348 Total Patients Enrolled
Australasian Gastro-Intestinal Trials GroupNETWORK
22 Previous Clinical Trials
7,673 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel
2013. "International Multicentre Study in Advanced Anal Cancer Comparing Cisplatin Plus 5 FU vs Carboplatin Plus Weekly Paclitaxel". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02051868.
All > Anal Cancer
~7 spots leftby Apr 2025
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