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Opioid Antagonist

Naltrexone for Alcoholism

Phase 2
Waitlist Available
Led By Lara Ray, PhD
Research Sponsored by University of California, Los Angeles
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up cue reactivity paradigm takes place on day 1 and on day 14. craving is measured 3 min after each cue exposure
Awards & highlights

Study Summary

This trial is testing whether naltrexone or varenicline can help people with AUD who are motivated to change their drinking. 108 people will be randomly assigned to receive naltrexone, varenicline, or a placebo, and then asked to complete an alcohol cue-reactivity paradigm and a 7-day practice quit attempt.

Eligible Conditions
  • Alcoholism

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~cue reactivity paradigm takes place on day 1 and on day 14. craving is measured 3 min after each cue exposure
This trial's timeline: 3 weeks for screening, Varies for treatment, and cue reactivity paradigm takes place on day 1 and on day 14. craving is measured 3 min after each cue exposure for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
# of Drinks Per Drinking Day
Cue-induced Craving
Percentage of Days Abstinent

Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: NaltrexoneActive Control1 Intervention
50 mg once a day
Group II: VareniclineActive Control1 Intervention
1 mg twice a day
Group III: PlaceboPlacebo Group1 Intervention
Matched to active medications

Find a Location

Who is running the clinical trial?

University of California, Los AngelesLead Sponsor
1,526 Previous Clinical Trials
10,275,851 Total Patients Enrolled
16 Trials studying Alcoholism
3,733 Patients Enrolled for Alcoholism
National Institute on Alcohol Abuse and Alcoholism (NIAAA)NIH
798 Previous Clinical Trials
1,361,528 Total Patients Enrolled
422 Trials studying Alcoholism
985,155 Patients Enrolled for Alcoholism
Lara Ray, PhDPrincipal Investigator - University of California, Los Angeles
Lucile Packard Children's Hospital at Stanford
Medical School - University of California, Irvine, Doctor of Medicine
Children's Hospital Los Angeles (Residency)
6 Previous Clinical Trials
307 Total Patients Enrolled
6 Trials studying Alcoholism
307 Patients Enrolled for Alcoholism

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
A Novel Human Lab Model for Screening AUD Medications
Lara Ray, PhD 2020. "A Novel Human Lab Model for Screening AUD Medications". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04249882.
~10 spots leftby Apr 2025
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