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Mifepristone for Addison's Disease

Phase 2

Waitlist Available

Led By Tobias Else, MD

Research Sponsored by Tobias Else

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 88 days

Awards & highlights

Study Summary

This trial is to test if mifepristone is a good way to test for CAI and if it is effective.

Eligible Conditions

Addison's Disease
Mifepristone

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 88 days

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 88 days

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 88 days for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Number of Study Participants Recruited

Number of Study Participants With Complete Study Data Captured

Secondary outcome measures

Absolute ACTH After Mifepristone

Peak Cortisol Measured After Mifepristone

Side effects data

From 2016 Phase 4 trial • 8 Patients • NCT01990560

13%

Drug Rash

13%

Hypokalemia

100%

80%

60%

40%

20%

Study treatment Arm

Mifepristone

Trial Design

1Treatment groups

Experimental Treatment

Group I: MifepristoneExperimental Treatment1 Intervention

Patients will be provided a single dose of 600 milligram (mg) mifepristone to be administered orally, and subjects will be instructed to take the drug between 10PM and 11PM on Day 1.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Mifepristone

2013

Completed Phase 4

~3080

Do I qualify?Apply below to find out

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Who is running the clinical trial?

Tobias ElseLead Sponsor

Corcept TherapeuticsIndustry Sponsor

68 Previous Clinical Trials

6,377 Total Patients Enrolled

Tobias Else, MDPrincipal Investigator - University of Michigan

University of Michigan C.S. Mott Children's Hospital, University of Michigan Hospital, Von Voigtlander Women's Hospital

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What medical conditions are commonly addressed by treatment with Mifepristone?

"Mifepristone is a proven therapeutic aid when dealing with medical interventions such as hyperglycemia and abortions."

Answered by AI

Has the FDA sanctioned using Mifepristone for medical treatments?

"Mifepristone is deemed safe enough to have earned a score of 2, as there is some evidence that it does not pose an inherent risk and clinical trials are being conducted in order to confirm its efficacy."

Answered by AI

Can you elaborate on the research performed with regards to Mifepristone?

"Currently, 10 investigation projects are being conducted that focus on Mifepristone. Two of them have reached Phase 3 status. Most trials occur in New york City, although there are 32 sites actively conducting research for this drug."

Answered by AI

What is the upper limit on participants for this research?

"Correct. According to clinicaltrials.gov, the study is actively recruiting participants and was originally posted on May 5th 2021. The last update to the trial occured on May 6th 2022 with a total of 26 patients being sought from 1 medical centre."

Answered by AI

Are there any vacancies left for participants in this research project?

"According to official information hosted on clinicaltrials.gov, this trial is currently enrolling patients. It was initially made public on May 5th 2021 and has since been revised as of June 5th 2022."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency

Tobias Else 2021. "Mifepristone Dynamic Testing for Diagnosis for Central Adrenal Insufficiency". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04588688.