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Total Intravenous Anesthesia for Cancer Surgery

Phase 2

Recruiting

Led By Aslam Ejaz, MD

Research Sponsored by Ohio State University Comprehensive Cancer Center

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Diagnosed with pancreatic adenocarcinoma

Adults: >= 18 years

Timeline

Screening 3 weeks

Treatment Varies

Follow Up up to 2 years

Awards & highlights

Study Summary

This trial is studying TIVA as an alternative to traditional anesthesia during cancer surgery, which may reduce immunosuppression.

Who is the study for?

This trial is for adults over 18 who have been diagnosed with pancreatic adenocarcinoma and are scheduled for surgery between January 1, 2021, and December 31, 2023. Participants must be able to consent but cannot join if they're prisoners, allergic to Propofol (the study anesthetic), or have a history of malignant hyperthermia from inhaled anesthetics.Check my eligibility

What is being tested?

The TIVACS Study is examining the effects of total intravenous anesthesia (TIVA) after cancer surgery. It's comparing TIVA's benefits like less nausea and quicker bowel function recovery against traditional general anesthesia methods that use volatile agents.See study design

What are the potential side effects?

While not explicitly stated, potential side effects may include typical anesthesia risks such as reactions at the injection site, headache, dizziness or muscle pain. Since TIVA uses Propofol, there could also be a risk of low blood pressure or changes in heart rate.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I have been diagnosed with pancreatic cancer.

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I am 18 years old or older.

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I had surgery between January 1, 2021, and December 31, 2023.

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ up to 2 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~up to 2 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and up to 2 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Impact of anesthetic agent on inflammation and immunosuppression

Secondary outcome measures

Impact of anesthetic choice on short-term anesthetic and surgical outcomes

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Arm I (surgical resection with TIVA)Experimental Treatment2 Interventions

Patients undergo surgical resection with TIVA.

Group II: Arm II (surgical resection with inhaled volatile anesthetics)Active Control2 Interventions

Patients undergo surgical resection with inhaled volatile anesthetics.

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Anesthesia Procedure

2020

N/A

~80

Resection

2021

Completed Phase 2

~410

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

Ohio State University Comprehensive Cancer CenterLead Sponsor

320 Previous Clinical Trials

290,087 Total Patients Enrolled

Aslam Ejaz, MDPrincipal InvestigatorOhio State University Comprehensive Cancer Center

Media Library

Anesthesia Procedure (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04992507 — Phase 2

Pancreatic Adenocarcinoma Research Study Groups: Arm I (surgical resection with TIVA), Arm II (surgical resection with inhaled volatile anesthetics)

Pancreatic Adenocarcinoma Clinical Trial 2023: Anesthesia Procedure Highlights & Side Effects. Trial Name: NCT04992507 — Phase 2

Anesthesia Procedure (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04992507 — Phase 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Has the FDA validated Resection for therapeutic use?

"Although there is evidence of Resection's safety, due to its status as a Phase 2 trial, it can only be scored at 2 in terms of security."

Answered by AI

Are any new participants being considered for this experiment?

"The details posted on clinicaltrials.gov demonstrate that this particular medical trial is no longer accepting participants; it was initially launched January 1st 2023 and last edited November 23rd 2022. Nonetheless, there are 788 other trials currently recruiting individuals for their research."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Impact of Total Intravenous Anesthesia Following Cancer Surgery, TIVACS Study

Aslam Ejaz 2023. "Impact of Total Intravenous Anesthesia Following Cancer Surgery, TIVACS Study". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04992507.

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