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Alkylating agents

Radiation Therapy for Endometrial Adenocarcinoma

Phase 3

Waitlist Available

Led By Joyce N Barlin, MD

Research Sponsored by Women's Cancer Care Associates, LLC

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Be older than 18 years old

Timeline

Screening 3 weeks

Treatment Varies

Follow Up from study entry to death or date of last contact, assessed up to 8 years

Awards & highlights

Study Summary

This trial is testing whether a certain combination of drugs is better than another combination of drugs at reducing the rate of cancer recurrence.

Eligible Conditions

Uterine Corpus Cancer
Endometrial Adenocarcinoma
Endometrial Carcinoma
Uterine Cancer

Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ from study entry to death or date of last contact, assessed up to 8 years

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~from study entry to death or date of last contact, assessed up to 8 years

This trial's timeline: 3 weeks for screening, Varies for treatment, and from study entry to death or date of last contact, assessed up to 8 years for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Recurrence-free survival (RFS)

Secondary outcome measures

Overall survival (OS)

Other outcome measures

Incidence of acute and adverse effects as graded by the NCI Common Toxicity Criteria for Adverse Events version (CTCAE) version 4.0

Trial Design

2Treatment groups

Experimental Treatment

Active Control

Group I: Regimen IExperimental Treatment4 Interventions

Cisplatin 50 mg/m2 IV Days 1 and 29 plus Volume-directed radiation therapy followed by Carboplatin AUC 5 or 6 plus Paclitaxel 175 mg/m2 q 21 days for 4 cycles

Group II: Regimen IIActive Control3 Interventions

Carboplatin AUC 6 plus Paclitaxel 175 mg/m2 q 21 days for 3 cycles followed by Volume-directed radiation therapy followed by Carboplatin AUC 5 or 6 plus Paclitaxel 175 mg/m2 q 21 days for 3 cycles

Treatment

First Studied

Drug Approval Stage

How many patients have taken this drug

Radiation Therapy

2017

Completed Phase 3

~7250

Cisplatin

2013

Completed Phase 3

~1940

Paclitaxel

2011

Completed Phase 4

~5380

Carboplatin

2014

Completed Phase 3

~6670

Do I qualify?Apply below to find out

Find a Location

Who is running the clinical trial?

Women's Cancer Care Associates, LLCLead Sponsor

Joyce N Barlin, MDPrincipal InvestigatorWomen's Cancer Care Associates, LLC

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Are there previous examples of using radiation to treat patients?

"City of Hope Comprehensive Cancer Center first researched Radiation Therapy in 1997. Since then, 2340 trials have completed and 1592 studies are ongoing. A large number of these active studies are based in Columbus, Ohio."

Answered by AI

Are there any new participants needed for this research project?

"This study is no longer recruiting patients for clinical trials. The first posting was on March 1st, 2015 and the last update was on April 25th, 2022. However, there are 824 other trials for adenocarcinoma and 1592 trials for Radiation Therapy that are still recruiting patients."

Answered by AI

Where can I find a list of facilities where this research is being conducted?

"The trial is being hosted at The Ohio State University, Munson Health Care, and Atlantic Health, as well as 7 other locations."

Answered by AI

For what reasons is Radiation Therapy most often employed?

"While it is commonly used to treat endometrial cancer that has progressed, radiation therapy can also be used to target other conditions such as melanoma, neoplasm metastasis, lymphoma, and non-hodgkin."

Answered by AI

How many test subjects are being given this medication?

"As of right now, this particular trial is not enrolling patients. It was initially posted on March 1st, 2015 and was updated on April 25th, 2022. For those still seeking clinical trials, there are 824 trials for adenocarcinoma, clear cell and 1592 radiation therapy trials that are currently enrolling patients."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Trial of Cisplatin Plus Radiation Followed by Carbo and Taxol Vs. Sandwich Therapy of Carbo and Taxol Followed Radiation Then Further Carbo and Taxol

Joyce N. Barlin, MD 2015. "Trial of Cisplatin Plus Radiation Followed by Carbo and Taxol Vs. Sandwich Therapy of Carbo and Taxol Followed Radiation Then Further Carbo and Taxol". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02501954.