Radiation Therapy for Adenocarcinoma
This study is evaluating whether radiation therapy, paclitaxel, and carboplatin with or without trastuzumab work in treating patients with esophageal cancer.
See full descriptionAbout the trial for Adenocarcinoma
Treatment Groups
This trial involves 2 different treatments. Radiation Therapy is the primary treatment being studied. Participants will be divided into 2 treatment groups. There is no placebo group. The treatments being tested are in Phase 3 and have had some early promising results.
About The Treatment
Eligibility
This trial is for patients born any sex aged 18 and older. There are 10 eligibility criteria to participate in this trial as listed below.
Approximate Timelines
Measurement Requirements
This trial is evaluating whether Radiation Therapy will improve 1 primary outcome and 7 secondary outcomes in patients with Adenocarcinoma. Measurement will happen over the course of At the time of surgery, 5-8 weeks after completion of radiation therapy..
Patient Q & A Section
What are the signs of adenocarcinoma?
The most discriminating signs of an adenocarcinoma are the presence of lysis in the lymph vessels, hemorrhaging outside the capsule, and enlargement of the lymph node capsule in the neck.
How many people get adenocarcinoma a year in the United States?
The incidence of adenocarcinoma is increasing in all racial, age, and sex categories. The incidence of adenocarcinoma in the entire population rose from 37.2 per 100,000 population in 1990 to 54.7 per 100,000 population in 2000.
What are common treatments for adenocarcinoma?
It is important that providers and patients discuss commonly used treatments and follow-up care in order to reduce unmet care needs. In addition, care can be delivered in a more effective and timely fashion by addressing patient barriers to care, and the patient's care needs are better met if physicians have the most up-to-date knowledge about the disease and protocols for appropriate treatment.
What causes adenocarcinoma?
There are 3 major causes of adenocarcinoma and most arise from digestive or respiratory system. The most common is stomach malignancies and the second most common is uterothread cancers. As for respiratory system malignancies, most occurred in lung cancer.\n
What is adenocarcinoma?
Adenocarcinoma of the oesophagus and gastro-oesophageal junction are two of the more common forms of oesophageal cancer. A careful examination of the upper GI tract during endoscopic or surgical procedures is essential to facilitate the appropriate diagnosis and to guide treatment.\n
Can adenocarcinoma be cured?
Adenocarcinoma can be cured by an adjuvant therapy, such as chemotherapy, which was introduced into the treatment of lung adenocarcinomas less than 35 years ago.
How quickly does adenocarcinoma spread?
Adenocarcinoma is a fast-growing aggressive cancer that usually spreads very quickly into and beyond the larynx, and it can invade the neck and the lungs. Adenocarcinoma of the larynx is the most common site for local and regional disease spread. Even if it escapes the head and neck region, adenocarcinoma can cause massive distant spread by periductal and perineural invasion to the distant lymph nodes or lungs.
What is radiation therapy?
Radiation therapy has been used for many years and it has been associated with fewer side effects and more positive clinical outcomes. It could be used as an alternative in patients with locally advanced non-operable carcinoma, in the patients with limited disease, in the patients with a known N2 disease and in the patients who are not candidates for surgery, and radiation remains the standard of care. Furthermore, the majority of patients in our series did not require subsequent surgery, and a number of patients have been followed up to more than five years after the end of treatment. It is important to remember that, even though local control rates have increased, overall survival remains low. Nevertheless, the authors of this series urge more effort into optimizing radiation dosage protocols.
What is the primary cause of adenocarcinoma?
Adenocarcinoma may represent either a neoplastic process or an exogenous cause. The cause of adenocarcinoma by tumor type should be considered when evaluating the pathogenesis of adenocarcinoma.
What are the common side effects of radiation therapy?
Radiation induced dermatitis occurred with a relatively high frequency (>30%), and was associated with the duration of exposure in most patients. Some physicians may feel they can control dermatitis by changing the radiation schedule or delivery technique. However, the treatment should be adjusted based on the skin toxicity that develops.
How does radiation therapy work?
In both [small cell lung cancer](https://www.withpower.com/clinical-trials/small-cell-lung-cancer) and non-small cell lung cancer, radiation therapy was found to be an effective treatment. To find out when it is optimal to give radiation therapy to a person, one must assess the risks and benefits of radiation therapy to the patient.
Is radiation therapy typically used in combination with any other treatments?
Overall, the results of this research indicate that combination therapies should be the procedure of choice in the treatment of T4 breast cancer to decrease the risk of local recurrence and to improve the quality of life of patients.