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Ultrasound guided Liposomal Bupivacaine Erector Spinae Block for Postoperative Pain

Phase 3
Waitlist Available
Led By Yar Yeap, MD
Research Sponsored by Indiana University
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
ASA 1,2,3 or 4
Patient undergoing VATS including but not limited to wedge or lobectomy at Indiana University Hospital
Timeline
Screening 3 weeks
Treatment Varies
Follow Up sedation scores will be documented at 1 hour post op, 24,48,and 72 hours after the block. the scores will then be averaged.]
Awards & highlights

Study Summary

This trial is comparing the effects of 2 different types of pain relief after surgery; one with a block, one with a drug infusion. Outcomes include pain, opioid use, side effects, & patient satisfaction.

Eligible Conditions
  • Postoperative Pain
  • Acute Pain
  • Thoracic

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~opioid consumption will be measured at 1 hour post op, 24,48, and 72 hours post op. the total amount will be recorded.]
This trial's timeline: 3 weeks for screening, Varies for treatment, and opioid consumption will be measured at 1 hour post op, 24,48, and 72 hours post op. the total amount will be recorded.] for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
The Primary endpoint of this study will be VAS pain score at 24 hours
The Primary endpoint of this study will be VAS pain score at.48 hours
Secondary outcome measures
Average Nausea scores over 72 hours
Average Sedation scores over 72 hours
Secondary endpoint includes total opioid consumption at 72 hours
+2 more

Trial Design

3Treatment groups
Active Control
Group I: Ultrasound guided Liposomal Bupivacaine Erector Spinae BlockActive Control2 Interventions
All the erector spinae plane blocks will be placed preoperatively using Liposomal Buvicaine. All procedures will be placed under the supervision of the attending anesthesiologist on the acute pain service or the attending anesthesiologist in the operating room.
Group II: Ultrasound guided Standard Bupivacaine Erector Spinae BlockActive Control1 Intervention
All the erector spinae plane blocks will be placed preoperatively using Liposomal Buvicaine. All procedures will be placed under the supervision of the attending anesthesiologist on the acute pain service or the attending anesthesiologist in the operating room.
Group III: Surgeon InfiltrationActive Control2 Interventions
At the end of the surgery, the surgeon will infiltrate liposomal bupivacaine under thoracoscopic guidance along the intercostal nerves from T4-T8.

Find a Location

Who is running the clinical trial?

Indiana UniversityLead Sponsor
973 Previous Clinical Trials
982,725 Total Patients Enrolled
5 Trials studying Postoperative Pain
1,902 Patients Enrolled for Postoperative Pain
Yar Yeap, MDPrincipal Investigator - Indiana University
Indiana University
6 Previous Clinical Trials
665 Total Patients Enrolled
1 Trials studying Postoperative Pain
70 Patients Enrolled for Postoperative Pain

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
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~21 spots leftby Mar 2025