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Nonsteroidal Anti-inflammatory Drug

Ketorolac Tromethamine 10 MG/ML for Pain relief (KETO-APP Trial)

Phase 3
Waitlist Available
Led By Mohamed Eltorki, MBChB
Research Sponsored by Hamilton Health Sciences Corporation
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be younger than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 24 hours
Awards & highlights

KETO-APP Trial Summary

This trial will help researchers understand if ketorolac is just as effective as morphine in relieving abdominal pain in children and adolescents who come to the pediatric emergency department.

Eligible Conditions
  • Pain relief
  • Childhood
  • Emergency
  • Appendicitis
  • Abdominal Pain

KETO-APP Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~24 hours
This trial's timeline: 3 weeks for screening, Varies for treatment, and 24 hours for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Feasibility Outcomes
Secondary outcome measures
Declining consent
Study Satisfaction
full study completion
+1 more
Other outcome measures
Clinical Outcomes

KETO-APP Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Ketorolac TromethamineExperimental Treatment1 Intervention
IV ketorolac tromethamine, 0.5 mg/kg to a maximum of 30 mg plus IV morphine placebo;
Group II: Morphine SulfateActive Control1 Intervention
IV morphine 0.1 mg/kg to a maximum of 5 mg plus IV ketorolac placebo
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Ketorolac Tromethamine 10 MG/ML
2021
Completed Phase 3
~110

Find a Location

Who is running the clinical trial?

Hamilton Health Sciences CorporationLead Sponsor
368 Previous Clinical Trials
300,896 Total Patients Enrolled
Mohamed Eltorki, MBChBPrincipal InvestigatorMcMaster University
1 Previous Clinical Trials
495 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Ketorolac Tromethamine 10 MG/ML safe for public consumption?

"Ketorolac Tromethamine 10 MG/ML is a Phase 3 medication, so it has received a score of 3 for safety. This means that there is both efficacy and multiple rounds of data supporting safety."

Answered by AI

Will patients who are over the age of 75 still be able to reap the benefits of this trial?

"According to the rules governing who can participate in this trial, the youngest patients that can be enrolled are 6 years old while the oldest eligible participants are 17."

Answered by AI

How many patients are enrolled in this clinical trial?

"Yes, this is an ongoing study that was first posted on May 5th, 2021 and updated February 13th, 2022. They are looking for 100 participants at a single site."

Answered by AI

Who meets the requirements to take part in this experiment?

"100 children aged 6 to 17 who present with abdominal pain at the emergency room will be admitted into this clinical trial. To meet the criteria for participation, patients must: have a physician or nurse's suspicion of appendicitis as reflected by the initiation of an appendicitis medical directive; have an IV cannula in place or ordered to be placed; have experienced moderate to severe pain for 5 days or less. Children ages 6 years old and younger are often atypical presentations of appendicitis and are thus excluded from the study."

Answered by AI

Are patients currently being enrolled in this trial?

"Yes, that is accurate. The clinical trial in question was posted on May 5th 2021 and last updated February 13th 2022. They are looking for 100 willing participants at a single location."

Answered by AI

What indications are there for Ketorolac Tromethamine 10 MG/ML?

"This medication, Ketorolac Tromethamine 10 MG/ML, is most often given to patients in order to relieve ocular itching. However, it can also serve as an effective treatment for pain, pupil dilation, and induction of nerve block."

Answered by AI

What are other examples of clinical trials using Ketorolac Tromethamine 10 MG/ML?

"As of right now, there are 97 ongoing studies into Ketorolac Tromethamine 10 MG/ML with 21 trials in the third and final phase. The majority of these clinical investigations are taking place in Boston, but Ketorolac Tromethamine 10 MG/ML is also being trialed at 189 other locations."

Answered by AI
~27 spots leftby Apr 2025